- PIMARIC ACID
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- $1.00 / 1KG
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2019-12-26
- CAS:127-27-5
- Min. Order: 1KG
- Purity: 85.0-99.8%
- Supply Ability: 20 tons
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| | PIMARIC ACID Basic information |
| Product Name: | PIMARIC ACID | | Synonyms: | (1R,4aR,4bS,7S,10aR)-7-Ethenyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-1,4a,7-triMethyl-1-phenanthrenecarboxylic Acid;13α-Methyl-13-vinylpodocarp-8(14)-en-15-oic acid;PIMARIC ACID;1-phenanthrenecarboxylicacid,7-ethenyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahyd;7-trimethyl-,[1theta-(1alpha,4abeta,4balpha,7beta,10aalpha)]-ro-4a;13-alpha-methyl-13-vinylpodocarp-8(14)-en-15-oic acid;1-Phenanthrenecarboxylic acid, 7-ethenyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-1,4a,7-trimethyl-, (1R,4aR,4bS,7S,10aR)-;8(14),15-PiMaradien-18-oic Acid | | CAS: | 127-27-5 | | MF: | C20H30O2 | | MW: | 302.45 | | EINECS: | | | Product Categories: | Activators;Aliphatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 127-27-5.mol |  |
| | PIMARIC ACID Chemical Properties |
| Melting point | 217-219° | | alpha | D18 +74.7° (c = 0.4 in chloroform); D20 +87.3° (in chloroform) | | Boiling point | bp18 282° | | density | 1.0434 (rough estimate) | | refractive index | 1.4800 (estimate) | | storage temp. | Store at -20°C | | solubility | DMSO: soluble,Water: soluble | | pka | 4.68±0.60(Predicted) | | form | Solid | | color | White to off-white | | LogP | 6.731 (est) | | EPA Substance Registry System | Pimaric acid (127-27-5) |
| | PIMARIC ACID Usage And Synthesis |
| Description | Pimaric acid is a resin acid that has been found in A. cordata and various pines. It reduces mRNA expression, protein levels, and promoter activity of matrix metalloproteinase-9 (MMP-9) in TNF-α-stimulated human aortic smooth muscle cells (HASMCs) in a concentration-dependent manner when used at concentrations ranging from 5 to 20 μM. Pimaric acid (10-20 μM) reduces nuclear expression and binding of the transcription factors NF-κB and AP-1 to the MMP-9 promoter in HASMCs. Pimaric acid also reduces TNF-α-induced HASMC migration to control levels when used at a concentration of 20 μg/ml. | | Uses | A novel activators of large-conductance Ca2+-activated K+ channel α-subunit. | | Definition | ChEBI: (+)-Pimaric acid is a diterpenoid. |
| | PIMARIC ACID Preparation Products And Raw materials |
| Preparation Products | PIMAROL-->(1R)-7β-Ethenyl-1,2,3,4,4a,5,6,7,8,9,10,10aα-dodecahydro-1,4aβ,7-trimethyl-1α-phenanthrenecarboxylic acid methyl ester |
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