- Manidipine
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- $15.00 / 1KG
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2021-07-13
- CAS:89226-50-6
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- Manidipine
-
- $15.00 / 1KG
-
2021-07-10
- CAS:89226-50-6
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- Manidipine
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- $1.00 / 1g
-
2019-12-24
- CAS:89226-50-6
- Min. Order: 1g
- Purity: 99.99%
- Supply Ability: 200kg
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| Manidipine Basic information |
Product Name: | Manidipine | Synonyms: | 2-(4-Diphenylmethyl-1-piperazinyl)ethyl methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(4-(diphenylmethyl)-1-piperazinyl)ethyl methyl ester;89226-75-5 (Di-hydrochloride);1-diphenylmethyl-4-(2-hydroxyethyl)piperazine;3-{2-[4-(diphenylMethyl)piperazin-1-yl]ethyl} 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;Manidipine (Manyper);3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester | CAS: | 89226-50-6 | MF: | C35H38N4O6 | MW: | 610.7 | EINECS: | 855-394-4 | Product Categories: | Inhibitors;Artedil, Iperten;Dihydropyridine;Dihydropyridine Class Chemicals;Intermediates & Fine Chemicals;Pharmaceuticals | Mol File: | 89226-50-6.mol | |
| Manidipine Chemical Properties |
Melting point | 125-128°C | Boiling point | 722.0±60.0 °C(Predicted) | density | 1.232±0.06 g/cm3(Predicted) | storage temp. | Sealed in dry,2-8°C | solubility | Soluble in DMSO > 10 mM | form | Powder | pka | 6.12±0.10(Predicted) | LogP | 4.135 |
| Manidipine Usage And Synthesis |
Description | Manidipine is a dihydropyridine L- and T-type calcium channel blocker. It blocks recombinant rabbit L-type (α1Cα2/δβ1a) and human T-type (α1H) calcium channels expressed in Xenopus oocytes and native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 = 2.6 nM). Manidipine inhibits intracellular calcium increases induced by endothelin-1 (ET-1; ) in A7r5 rat vascular smooth muscle cells (ED50 = 1 nM) and potassium-induced contraction of isolated dog femoral and portal veins (IC50s = 24 and 2.1 nM, respectively). In vivo, it lowers blood pressure in spontaneously hypertensive rats (SHRs) when administered at a dose of 10 mg/kg and inhibits left ventricular hypertrophy in rats induced by isoproterenol when administered at a dose of 3 mg/kg. Formulations containing manidipine have been used in the treatment of hypertension. | Chemical Properties | Light Yellow Crystalline Solid | Uses | A dihydropyridine calcium channel blocker. Antihypertensive. | Uses | Manidipine (Manyper) is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. It causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. It | Definition | ChEBI: Manidipine is a diarylmethane. |
| Manidipine Preparation Products And Raw materials |
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