CC-92480 manufacturers
- Mezigdomide
-
- $118.00 / 1mg
-
2025-11-10
- CAS:2259648-80-9
- Min. Order:
- Purity: 98.80%
- Supply Ability: 10g
- Mezigdomide
-
- $118.00 / 1mg
-
2025-11-10
- CAS:2259648-80-9
- Min. Order:
- Purity: 98.80%
- Supply Ability: 10g
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| | CC-92480 Basic information |
| Product Name: | CC-92480 | | Synonyms: | CC-92480;CC92489;Benzonitrile, 4-[4-[[4-[[[2-[(3S)-2,6-dioxo-3-piperidinyl]-2,3-dihydro-1-oxo-1H-isoindol-4-yl]oxy]methyl]phenyl]methyl]-1-piperazinyl]-3-fluoro-;Mezigdomide;(S)-4-(4-(4-(((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile;RSYY（Avanafil)-4;CC 92480,Molecular Glues,Ubiquitin ligase,Ubiquitin activating enzyme,E1/E2/E3 Enzyme,Apoptosis,inhibit,E1 activating enzyme,Mezigdomide,E2 conjugating enzyme,Inhibitor,Ubiquitin conjugating enzyme,CC92480,E3 ligating enzyme;Avanafil Impurity 80 | | CAS: | 2259648-80-9 | | MF: | C32H30FN5O4 | | MW: | 567.61 | | EINECS: | | | Product Categories: | | | Mol File: | 2259648-80-9.mol |  |
| | CC-92480 Chemical Properties |
| Boiling point | 833.0±65.0 °C(Predicted) | | density | 1.41±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: soluble | | form | A solid | | pka | 10.70±0.40(Predicted) | | color | White to off-white | | InChIKey | YTINZZFBHWSAGL-NDEPHWFRSA-N | | SMILES | C(#N)C1=CC=C(N2CCN(CC3=CC=C(COC4=CC=CC5=C4CN([C@H]4CCC(=O)NC4=O)C5=O)C=C3)CC2)C(F)=C1 |
| | CC-92480 Usage And Synthesis |
| Uses | Mezigdomide (CC-92480), a cereblon E3 ubiquitin ligase modulating agent (CELMoD), acts as a molecular glue. Mezigdomide shows high affinity to cereblon, resulting in potent antimyeloma activity[1]. | | References | [1] Nooka AK, et al. Mechanism of Action and Novel IMiD-Based Compounds and Combinations in Multiple Myeloma. Cancer J. 2019 Jan/Feb;25(1):19-31. DOI:10.1097/PPO.0000000000000354 |
| | CC-92480 Preparation Products And Raw materials |
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