MI-1061 manufacturers
- MI-1061
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- $3598.00 / 25mg
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2025-08-21
- CAS:1410737-34-6
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | MI-1061 Basic information |
| Product Name: | MI-1061 | | Synonyms: | MI-1061;Benzoic acid, 4-[[[(3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-1'',2''-dihydro-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-[3H]indol]-5'-yl]carbonyl]amino]-;MI1061,MI 1061 | | CAS: | 1410737-34-6 | | MF: | C30H26Cl2FN3O4 | | MW: | 582.45 | | EINECS: | | | Product Categories: | | | Mol File: | 1410737-34-6.mol |  |
| | MI-1061 Chemical Properties |
| Boiling point | 808.2±65.0 °C(Predicted) | | density | 1.51±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 300 mg/mL (515.07 mM) | | form | Solid | | pka | 4.22±0.10(Predicted) | | color | White to off-white |
| | MI-1061 Usage And Synthesis |
| Description | MI-1061 is a novel Chemically Stable, Potent, and Efficacious MDM2 Inhibitor. | | Uses | MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity[1]. | | in vivo | MI-1061 (100 mg/kg; p.o.; daily for 14 days) is capable of achieving tumor regression in the SJSA-1 xenograft tumor model in mice[1]. | Animal Model: | SCID mice bearing SJSA-1 osteosarcoma xenografts[1] | | Dosage: | 100 mg/kg | | Administration: | P.o.; daily for 14 days | | Result: | Demonstrated strong antitumor activity and achieved significant tumor regression.
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| | References | [1] Aguilar A, et al. Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannichring-opening-cyclization reaction mechanism in spiro-oxindoles. J Med Chem. 2014 Dec 26;57(24):10486-98. DOI:10.1021/jm501541j |
| | MI-1061 Preparation Products And Raw materials |
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