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Product Name:IACS-8779
CAS:2243079-26-5
Purity:>98% Remarks:IACS-8779 is a highly potent agonist of stimulator of interferon genes (STING) with robust systemic antitumor efficacy. IACS-8779 shows robust activation of the STING pathway in vitro and a superior s
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| | IACS-8779 Basic information |
| Product Name: | IACS-8779 | | Synonyms: | IACS-8779;IACS8779,IACS 8779;(1R,3R,6R,8R,9R,10S,12R,15R,17R)-8-{4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-17-(6-amino-9H-purin-9-yl)-9,18-dihydroxy-3,12-disulfanyl-2,4,7,11,13,16-hexaoxa-3λ?,12λ?-diphosphatricyclo[13.2.1.0?,1?]octadecane-3,12-dione | | CAS: | 2243079-26-5 | | MF: | C21H25N9O10P2S2 | | MW: | 689.55 | | EINECS: | | | Product Categories: | | | Mol File: | 2243079-26-5.mol |  |
| | IACS-8779 Chemical Properties |
| Boiling point | 1006.4±75.0 °C(Predicted) | | density | 2.33±0.1 g/cm3(Predicted) | | pka | -0.73±0.70(Predicted) |
| | IACS-8779 Usage And Synthesis |
| Uses | IACS-8779 is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy[1]. | | in vivo | Mice are implanted bilaterally with B16-Ova, and IACS-8779 (compound 1a) is administered at 10 μg dose with three intra-tumoral injections, on one flank only, on day 6, 9, 12 post implantation. While IACS-8779 shows comparable antitumor activity on the injected flank, IACS-8779 achieves superior regression on the untreated tumor in the contralateral flank, suggesting a more significant systemic immune response compared to the benchmark analogs. Treatment with IACS-8779 also results in a higher number of mice cured of both tumors compared to benchmarks[1]. | | References | [1] Ager CR, et al. Discovery of IACS-8803 and IACS-8779, potent agonists of stimulator of interferon genes (STING) with robust systemic antitumor efficacy. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126640. DOI:10.1016/j.bmcl.2019.126640 |
| | IACS-8779 Preparation Products And Raw materials |
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