|
|
| | DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Basic information |
| | DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Chemical Properties |
| Boiling point | 96°C 15mm | | density | 1.193 | | refractive index | n20/D 1.388(lit.) | | Fp | 113 °C | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Oil | | Specific Gravity | 1.193 | | color | Clear Colourless | | InChI | InChI=1S/C5H11F2O3P/c1-3-9-11(8,5(6)7)10-4-2/h5H,3-4H2,1-2H3 | | InChIKey | VVFGLBKYBBUTRO-UHFFFAOYSA-N | | SMILES | P(C(F)F)(=O)(OCC)OCC |
| Hazard Codes | Xi | | Risk Statements | 34 | | Safety Statements | 26-36/37/39 | | RIDADR | 3265 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29319090 |
| | DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Usage And Synthesis |
| Chemical Properties | Colourless Liquid | | Uses | Inhibitor of bacterial phosphotriesterases and an intermediate for the synthesis of 5’-diphosphate/5’-triphosphate mimics for transcriptase and glycerol kinase inhibition. | | Synthesis Reference(s) | Tetrahedron Letters, 23, p. 2323, 1982 DOI: 10.1016/S0040-4039(00)87332-3 | | Synthesis | Diethyl Difluoromethylphosphonate is prepared by the reaction of sodium diethyl phosphite with Chlorodifluoromethane in hexane (49% yield) or in THF (77% yield) or generated in situ from diethyl bromodifluoromethylphosphonate and BuLi.
|
| | DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Preparation Products And Raw materials |
|