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MINAPRINE DIHYDROCHLORIDE

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Products Intro: Product Name:Minaprine dihydrochloride;Minaprine;Cantor;Minaprinum;Minaprina;Minaprina
CAS:25905-77-5
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Products Intro: Product Name:MINAPRINE DIHYDROCHLORIDE
CAS:25905-77-5
Purity:0.99 Package:5KG;1KG
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Products Intro: Product Name:Minaprine dihydrochloride;Minaprine;Cantor;Minaprinum;Minaprina;Minaprina
CAS:25905-77-5
Purity:99.00% Package:25 mg;50 mg;100 mg;200 mg;1 mL * 10 mM (in DMSO) Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:Minaprin
CAS:25905-77-5
Purity:Typically NLT 98%
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Products Intro: Product Name:Minaprine
CAS:25905-77-5
Remarks:Minaprine, also called as Agr 1240 or Cantor, an atypical antidepressant drug which is effective in most animal models of depression, is a reversible inhibitor of MAO-A and weakly inhibits acetylcholi
MINAPRINE DIHYDROCHLORIDE Basic information
Product Name:MINAPRINE DIHYDROCHLORIDE
Synonyms:n-(4-methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamin;n-(4-methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine;minaprin;Minaprin diHCl;N-(4-Methyl-6-phenylpyridazin-3-yl)-4-morpholineethanamine;TS-370;N-[4-METHYL-6-PHENYL-3-PYRIDAZINYL]-4-MORPHOLINEETHANAMINE DIHYDROCHLORIDE;MINAPRIN DIHYDROCHLORIDE
CAS:25905-77-5
MF:C17H22N4O
MW:298.38
EINECS:247-329-8
Product Categories:Active Pharmaceutical Ingredients;NAMENDA
Mol File:25905-77-5.mol
MINAPRINE DIHYDROCHLORIDE Structure
MINAPRINE DIHYDROCHLORIDE Chemical Properties
Melting point 122°
Boiling point 531.2±50.0 °C(Predicted)
density 1.156±0.06 g/cm3(Predicted)
pka6.80±0.10(Predicted)
form neat
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 36
WGK Germany 3
RTECS QE3477830
MSDS Information
ProviderLanguage
SigmaAldrich English
MINAPRINE DIHYDROCHLORIDE Usage And Synthesis
OriginatorCantor,Clin Midy,France,1979
Usesmuscle relaxant (skeletal)
Manufacturing Process(a) Preparation of the free base: A mixture comprising 0.1 mol (20.4 g) of 3-chloro-4-methyl-6-phenylpyridazine and 0.2 mol (26.2 g) of N-(2-aminoethyl)-morpholine in 100 ml of n-butanol, with a pinch of copper powder, was heatedunder reflux for 12 hours. At the end of this time, the hot solution was pouredinto 200 ml of cold water. The resulting mixture was filtered through asintered glass filter and the precipitate washed with ether. The filtrate and theether washings were placed in a separating funnel and extracted with two 150ml portions of ether. The ethereal layer was then extracted with about 250 mlof N sulfuric acid.
The acid solution was made alkaline with a 10% aqueous solution of sodiumcarbonate, and left to crystallize overnight.
The solution was filtered, yielding the colorless needles which wererecrystallized from isopropanol. The yield was 15 g (53%).
(b) Preparation of the hydrochloride: The base was dissolved in the smallestamount possible of anhydrous acetone. Double that volume of anhydrousether was added, and a stream of hydrogen chloride gas was passed throughthe solution. The hydrochloride salt obtained was recrystallized from absolutealcohol. The yield after recrystallization was 17 g (90%).
Brand nameCantor (Sanofi).
Therapeutic FunctionAntidepressant
MINAPRINE DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials3-chloro-4-methyl-6-phenylpyridazine-->Hydrochloric acid-->4-(2-Aminoethyl)morpholine
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