色酚 AS-E
中文名称 | 色酚 AS-E |
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中文同义词 | 2-羟基-N-(4氯基苯基)-3-萘甲酰胺;N-(3-羟基-2-萘甲酰基)对氯苯胺;色酚 AS-E;冰染偶合组分 10;4'-氯-3-羟基-2-萘苯胺;纳夫妥AS-E;萘酚AS-E;C.I.冰染偶合组分10 |
英文名称 | Naphthol AS-E |
英文同义词 | NAPHTHOL AS-E;NAPTHOL AS-E;N-(4-CHLOROPHENYL)-3-HYDROXY-2-NAPHTHAMIDE;c.i. azoic coupling component 10;AZOIC COUPLING COMPONENT 10;4'-CHLORO-3-HYDROXY-2-NAPHTHANILIDE;AcnaNaphtholPC;DaitoGrounderE |
CAS号 | 92-78-4 |
分子式 | C17H12ClNO2 |
分子量 | 297.74 |
EINECS号 | 202-189-7 |
相关类别 | 冰染染料;染料;苯酚;色酚;原料;化工原料;染料中间体;Intermediates of Dyes and Pigments;Substrates;医药原料 |
Mol文件 | 92-78-4.mol |
结构式 |
色酚 AS-E 性质
熔点 | 255°C |
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沸点 | 416.5±30.0 °C(Predicted) |
密度 | 1.399±0.06 g/cm3(Predicted) |
蒸气压 | 0Pa at 25℃ |
储存条件 | Sealed in dry,Room Temperature |
溶解度 | 溶于二甲基甲酰胺 |
酸度系数(pKa) | 8.69±0.40(Predicted) |
色指数 | 37510 |
形态 | 米色固体 |
颜色 | 白色至淡黄色至深绿色 |
LogP | 2.97 at 23℃ and pH7.2 |
CAS 数据库 | 92-78-4(CAS DataBase Reference) |
EPA化学物质信息 | 2-Naphthalenecarboxamide, N-(4-chlorophenyl)-3-hydroxy- (92-78-4) |
KIX-KID 2.26 μM (IC 50 ) |
CREB (cyclic AMP-response element-binding protein) is a downstream transcription factor of a multitude of signaling pathways emanating from receptor tyrosine kinases or G-protein coupled receptors.CREB can not be activated until it is phosphorylated at Ser133 and its subsequent binding to CREB-binding protein (CBP) through the kinase-inducible domain (KID) in CREB and KID-interacting (KIX) domain in CBP.In a cell-based CREB Renilla luciferase reporter assay, Naphthol AS-E inhibits CREB-mediated gene transcription with an IC 50 of 2.29 µM. In HEK293T-based complementation assay, Naphthol AS-E dose-dependently inhibited Renilla luciferase activity with an IC 50 of 2.9 µM by directly binding to CBP's KIX domain (K d ~8.6 µM using a recombinant KIX).Naphthol AS-E exhibits low µM activity in inhibiting the proliferation of all these cancer cells, which is consistent with its cellular CREB inhibition potency. The average GI 50 values for A549, MCF-7, MDA-MB-231 and MDA-MB-468 are approximately 2.9µM, 2.81µM, 2.35µM and 1.46µM, respectively.Naphthol AS-E (2.5 µM-10 µM; 48 hours) decreases the expression of anti-apoptotic protein Bcl-2. The expression of VEGF is also decreased.
安全信息
海关编码 | 2924.29.7790 |
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