| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:BisindolylMaleiMide III
CAS:137592-43-9
Package:50Mg,5Mg
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:Bisindolylmaleimide III
CAS:137592-43-9
Purity:98% Package:1G;10G;100G Remarks:Bisindolylmaleimide III is a potent and selective inhibitor of PKC (protein kinase C) with structural similarity to the nonspecific PKC inhibitor staurosporine. It inhibits 93% of PKCα kinase activity
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| | BISINDOLYLMALEIMIDE III Basic information |
| | BISINDOLYLMALEIMIDE III Chemical Properties |
| Boiling point | 708.7±60.0 °C(Predicted) | | density | 1.41±0.1 g/cm3(Predicted) | | solubility | DMSO: soluble; Methanol: soluble | | form | A crystalline solid | | pka | 8.15±0.60(Predicted) |
| | BISINDOLYLMALEIMIDE III Usage And Synthesis |
| Description | Bisindolylmaleimide III was developed as a protein kinase C (PKC) inhibitor with structural similarity to the nonspecific PKC inhibitor staurosporine. At 1 μM, bisindolylmaleimide III inhibits 93% of PKCα kinase activity and also inhibits many other protein kinases including, S6K1, MAPKAP-K1, RSK2 and MSK1 with similar potency. Additionally, it inhibits PDK1, an important kinase in the insulin signaling pathway, with an IC50 value of 3.8 μM. | | Uses | Bisindolylmaleimide III is a protein kinase C inhibitor and was also shown to exhibit inhibitory activities towards PDK1, an important kinase in the insulin signaling pathway, | | Definition | ChEBI: Bisindolylmaleimide III is a member of maleimides and a member of indoles. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor. It is functionally related to a maleimide. |
| | BISINDOLYLMALEIMIDE III Preparation Products And Raw materials |
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