| Company Name: |
Merck KGaA |
| Tel: |
21-20338288 |
| Email: |
ordercn@merckgroup.com |
| Company Name: |
SIGMA-RBI |
| Tel: |
800 736 3690 (Orders) |
| Email: |
|
|
| | ANTI-TROPONIN T, BOVINE, CARDIAC Basic information |
| | ANTI-TROPONIN T, BOVINE, CARDIAC Chemical Properties |
| storage temp. | −20°C | | biological source | mouse |
| Hazard Codes | Xn | | Risk Statements | 21/22 | | Safety Statements | 36/37 | | WGK Germany | 3 | | Storage Class | 10 - Combustible liquids |
| | ANTI-TROPONIN T, BOVINE, CARDIAC Usage And Synthesis |
| Uses | Monoclonal Anti-Troponin T antibody produced in mouse has been used in following studies:
- Western blot analysis.
- Immunocytochemical analysis.
- Immunofluorescence.
| | General Description | Troponin T is a vital subunit of troponin. Troponin T is a comma or rod shaped protein with a length of 185-205 . Troponin T is positioned in the actin helix groove and is extended along the filament of troponin. Life span of serum troponin T is 120 minutes. N- terminal end of the protein is enriched in negatively charged residues and C- terminal end is enriched with positively charged residues. This uneven distribution of charges in troponin T facilitates its aggregation at physiological salt concentration. In humans, cardiac troponin T exists in four isoforms, out of which three are expressed in the fetus and one isoform is expressed in the adult heart. | | Biochem/physiol Actions | Troponin T is a subunit of troponin, which facilitates binding of troponin to tropomyosin. It also plays a crucial role in muscle contraction. Cardiac troponin T acts as a potential marker for the detection of acute myocardial infarction (MI). Apart from facilitating binding of troponin components to the actin-tropomyosin filament, it is has an essential role in the regulation of actomyosin ATPase activity. Cardiac troponin T gene mutation leads to hypertrophic cardiomyopathy. |
| | ANTI-TROPONIN T, BOVINE, CARDIAC Preparation Products And Raw materials |
|