|
|
| | 2-Amino-6-chlorobenzoic acid Basic information |
| | 2-Amino-6-chlorobenzoic acid Chemical Properties |
| Melting point | 158-160 °C (lit.) | | Boiling point | 250°C (rough estimate) | | density | 1.3246 (rough estimate) | | refractive index | 1.5560 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | Crystalline Powder | | pka | 0.97±0.10(Predicted) | | color | Light yellow to beige | | Water Solubility | Very soluble in water. Soluble in methanol. | | BRN | 2804041 | | InChIKey | SZCPTRGBOVXVCA-UHFFFAOYSA-N | | CAS DataBase Reference | 2148-56-3(CAS DataBase Reference) | | NIST Chemistry Reference | 2-Amino-6-chlorobenzoic acid(2148-56-3) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 29224999 |
| | 2-Amino-6-chlorobenzoic acid Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powder | | Uses | 2-Amino-6-chlorobenzoic acid is used as intermediate for medicine. | | Application | The tricyclohexyltin 2-amino-6-chlorobenzoate was synthesized by the reaction of the tricyclohexyltin hydroxide with the 2-amino-6-chlorobenzoic acid. | | Preparation | A, in the reaction vessel being provided with agitator, thermometer, reflux condenser, Dropping funnel, add cerium chloride 0.16mol, 4-hydroxy 3-methoxybenzene ethanol solution 0.19mol, Klorvess Liquid 400-500ml, control mixing speed and exist 160-190rpm, rising solution temperature, to 60-65°C, is slowly added to 2-chloro-6-nitrobenzoyl acid solution 0.13mol, sulfurous acid Hydrogen potassium solution 200ml, raises mixing speed to 260-310rpm, back flow reaction 5-7h；
B, reduction solution temperature, to 15-19°C, separate out solid, filter, and add diammonium hydrogen citrate solution 150-in filtrate 180ml, concentrating under reduced pressure, separate out solid, filter, dehydrant is dehydrated, brine, and pyridine solution washs, ethyl acetate solution Middle recrystallization, obtains crystal 2-amino-6-chlorobenzoic acid (C7H6ClNO2). |
| | 2-Amino-6-chlorobenzoic acid Preparation Products And Raw materials |
|