哈尔碱盐酸盐(水合)
| 中文名称 | 哈尔碱盐酸盐(水合) |
|---|---|
| 中文同义词 | 哈尔碱盐酸盐(水合);骆驼蓬碱盐酸盐;水合哈尔碱盐酸盐;盐酸-7-甲氧基-1-甲基-9H-吡啶并(3,4-B)吲哚;盐酸哈尔明;罗勒生物碱;哈尔明盐酸盐;盐酸去氢骆驼蓬碱 |
| 英文名称 | HARMINE HYDROCHLORIDE |
| 英文同义词 | HarMine.HC;7-METHOXY-1-METHYL-9H-PYRIDO[3,4-B]INDOLE HCL;(3,4-b)indole,7-Methoxy-1-Methyl-9h-pyrido(Monohydrochloride;BANISTERINE HYDROCHLORIDE;BANISTERIN HCL;HARMINE HCL;HARMINE HYDROCHLORIDE;4-b)indole,7-methoxy-1-methyl-9h-pyrido(monohydrochloride |
| CAS号 | 343-27-1 |
| 分子式 | C13H13ClN2O |
| 分子量 | 248.71 |
| EINECS号 | 206-443-8 |
| 相关类别 | 中草药成分;中药对照品;标准品;小分子抑制剂，天然产物;合成;植物提取物;对照品;植提标准品;中药标准品;医药原料;标准品-对照品;标准品-中药标准品;标准品 -中药标准品;植物成分单体;标准品，对照品;Alkaloids;Biochemistry;Indole Alkaloids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;化工原料;单体化合物 |
| Mol文件 | 343-27-1.mol |
| 结构式 |  |
哈尔碱盐酸盐(水合) 性质
| 熔点 | 265-270°C |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 溶于水（高达 25 mg/ml）。 |
| 形态 | 粉末 |
| 颜色 | 灰白色至淡绿色 |
| Merck | 14,4616 |
| 稳定性 | 可在-20°下蒸馏水溶液保存长达3个月。 |
| LogP | 3.173 (est) |
| CAS 数据库 | 343-27-1(CAS DataBase Reference) |
| EPA化学物质信息 | Harmine hydrochloride (343-27-1) |
| Target | Value |
|
DYRK1A
(Cell-free assay) | 33 nM |
|
MNB
(Cell-free assay) | 149 nM |
|
DYRK1B
(Cell-free assay) | 166 nM |
|
DYRK2
(Cell-free assay) | 1.9 μM |
Harmine inhibits tau phosphorylation by DYRK1A by selected DANDYs, with an IC 50 of 190 nM. Harmine negatively regulates homologous recombination (HR) by interfering Rad51 recruitment, resulting in severe cytotoxicity in hepatoma cells. Furthermore, NHEJ inhibitor Nu7441 markedly sensitizes Hep3B cells to the anti-proliferative effects of Harmine.
It is shown that brain water content is significantly increased in the TBI group. Treatment with Harmine significantly reduces the tissue water content at 1, 3 and 5 days, compared with the TBI group. Harmine treatment significantly reduces the escape latency at 3 and 5 days, compared with the TBI group. Post-TBI administration of Harmine significantly improves the motor function recovery of the rats at 1, 3 and 5 days following TBI, compared with the TBI group without Harmine treatment. The neuronal survival rate in the Harmine-treated group is significantly increased, compared with the TBI group. Administration of Harmine results in marked elevation in the expression of GLT-1, compared with the TBI group. The administration of Harmine significantly reduces the expression of caspase 3, compared with the TBI group.
药理药效:杀菌、止痒，抗银屑病作用，抗肿瘤作用。
安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 20/21/22-40 |
| 安全说明 | 22-36 |
| 危险品运输编号 | 1544 |
| WGK Germany | 3 |
| RTECS号 | MG9450000 |
| 危险等级 | 6.1(b) |
| 包装类别 | III |
| 海关编码 | 29339900 |
| 提供商 | 语言 |
|---|---|
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英文
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