| Company Name: |
Xi'an Qiyue Biotechnology Co., Ltd.
|
| Tel: |
400-400-6966-012-012 17778955912 |
| Email: |
2957605606@qq.com |
| Products Intro: |
Product Name:Tos-PEG2-NH2
CAS:1246286-33-8
Package:5mg
|
| Company Name: |
Aobolihui
|
| Tel: |
0917-18691729 18691729963 |
| Email: |
2553382659@qq.com |
| Products Intro: |
Product Name:2-(2-aminoethoxy)ethyl 4-methylbenzenesulfonate
CAS:1246286-33-8
Purity:99% Package:5KG;1KG
|
| Company Name: |
Xinyanpomei
|
| Tel: |
15850660754 |
| Email: |
15850660754@163.com |
| Products Intro: |
CAS:1246286-33-8
Purity:98% Package:100g
|
|
| | PROTAC Linker 27 Basic information |
| Product Name: | PROTAC Linker 27 | | Synonyms: | PROTAC Linker 27;Tos-PEG2-NH2;2-(2-aminoethoxy)ethyl 4-methylbenzenesulfonate;Ethanol, 2-(2-aminoethoxy)-, 1-(4-methylbenzenesulfonate);2-(2-aminoethoxy)ethyl 4-methylbenzene-1-sulfonate | | CAS: | 1246286-33-8 | | MF: | C11H17NO4S | | MW: | 259.32 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1246286-33-8.mol |  |
| | PROTAC Linker 27 Chemical Properties |
| Boiling point | 414.5±30.0 °C(Predicted) | | density | 1?+-.0.06 g/cm3(Predicted) | | pka | 8?+-.0.10(Predicted) |
| | PROTAC Linker 27 Usage And Synthesis |
| Biological Activity | Tos-PEG2-NH2 (PROTAC Linker 27) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
| | PROTAC Linker 27 Preparation Products And Raw materials |
|