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Cilomilast

Cilomilast Suppliers list
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Email: linda@hubeijusheng.com
Products Intro: Product Name:Cilomilast
CAS:153259-65-5
Purity:0.99 Package:5KG;1KG
Company Name: BOC Sciences
Tel: 1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:Cilomilast
CAS:153259-65-5
Purity:98%
Company Name: HENAN BON INDUSTRIAL CO.,LTD
Tel: 0371-55170695
Email: info@hnbon.com
Products Intro: CAS:153259-65-5
Purity:0.99 Package:25KG;5KG;1KG;500G
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: 86-18523575427
Email: sales@conier.com
Products Intro: Product Name:sb-207499
CAS:153259-65-5
Purity:0.99 Package:1kg
Company Name: career henan chemical co
Tel: 0086-371-86658258 13203830695
Email: factory@coreychem.com
Products Intro: Product Name:Cilomilast
CAS:153259-65-5
Purity:95-99% Package:1g;1USD

Cilomilast manufacturers

  • Cilomilast
  • $0.00-0.00 / KG
  • 2021-07-20
  • CAS:153259-65-5
  • Min. Order: 5mg
  • Purity: 99% HPLC
  • Supply Ability: 2000tons
  • Cilomilast
  • $15.00-10.00 / KG
  • 2021-07-13
  • CAS:153259-65-5
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Cilomilast
  • $15.00-10.00 / KG
  • 2021-07-10
  • CAS:153259-65-5
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
Cilomilast Basic information
Product Name:Cilomilast
Synonyms:4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclohexane-1-carboxylic acid;CS-515;SB 207499 - Cilomilast | Ariflo;4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)-1-cyclohexanecarboxylic acid;Cilomilast, SB 207499, Ariflo;"(cilomilast) 4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphenyl)cyclohexane-1-carboxylic acid";CILOMILAST;Clomilast
CAS:153259-65-5
MF:C20H25NO4
MW:343.42
EINECS:200-258-5
Product Categories:Inhibitor;Aromatics;13C & 2H Sugars;Carbohydrates & Derivatives;Intermediates & Fine Chemicals;Inhibitors;Pharmaceuticals
Mol File:153259-65-5.mol
Cilomilast Structure
Cilomilast Chemical Properties
Melting point 157°C
Boiling point 549.1±50.0 °C(Predicted)
density 1.21±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: soluble15mg/mL, clear
form powder
pka4.45±0.25(Predicted)
color white to beige
InChIKeyCFBUZOUXXHZCFB-OYOVHJISSA-N
Safety Information
WGK Germany 3
MSDS Information
Cilomilast Usage And Synthesis
Chemical PropertiesCilomilast is White Solid
UsesCilomilast is a selective phosphodiesterase 4 (PDE4) inhibitor and can be used in treatment of chronic obstructive pulmonary disease.
Mechanism of actionCilomilast contains the dialkoxyphenyl ring characteristic of selective PDE4 inhibitors. The ether oxygens hydrogen bond to a glutamine in the binding pocket, and the cyclopentyl ring adds additional hydrophobic interactions. The oxygen atoms of the carboxyl group form hydrogen bonds with water that is coordinated with Mg2+ located in the distal end of the binding pocket. Orally administered cilomilast is 96% bioavailable. Food does not interfere with the overall absorption; however, food does slow down the rate. Cilomilast is 99% bound to albumin in the plasma and is metabolized in the liver by CYP2C8. The metabolism is extensive and results in oxidation, carboxyl group glucuronidation, and dealkylation of the cyclopentyl group, followed by glucuronidation or sulfation.
PharmacokineticsCilomilast is rapidly absorbed following oral administration (96% bioavailability), has an elimination half-life of 7 hours, and is extensively metabolized, but not by cytochrom P450 enzymes. The drug shows considerably more selectivity than roflumilast toward PDE4D, and this might account for the common side effects of nausea and emesis. Studies regarding the benefits of cilomilast versus placebo in the treatment of asthma have not been very encouraging, but significant improvement was seen in clinical trials of cilomilast in the treatment of COPD. The side effects of diarrhea and nausea have been considerably higher with cilomilast versus placebo, but these effects generally are tolerable and self limiting.
Cilomilast Preparation Products And Raw materials
Tag:Cilomilast(153259-65-5) Related Product Information
2-PHENYL-5-(TRIFLUOROMETHYL)-OXAZOLE-4-CARBOXYLIC ACID, ETHYL ESTER ETHYL 5-METHYLOXAZOLE-4-CARBOXYLATE Ethyl 5-(4-chlorophenyl)oxazole-4-carboxylate 2-PHENYL-5-(TRIFLUOROMETHYL)-OXAZOLE-4-CARBOXYLICACID 5-PHENYL-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Cilomilast Montelukast Phenyl salicylate Montelukast sodium (Trifluoromethoxy)benzene Zafirlukast Cyano Methoxy 4-Methoxyphenol PHENYL VALERATE CARBOXYLIC ACID Tranilast 4-Methoxybenzyl cyanide