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Pyrene

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Company Name: Springchem New Material Technology Co.,Limited
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Products Intro: Product Name:Pyrene
CAS:129-00-0
Purity:99%,99.5% Package:1kg,10kg,25kg
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Products Intro: Product Name:pyrene
CAS:129-00-0
Purity:98% (Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
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CAS:129-00-0
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Products Intro: Product Name:Pyrene
CAS:129-00-0
Purity:98% Package:1KG;1USD
Company Name: Zhengzhou KeYulong chemical products Co., Ltd  Gold
Tel:0371-53335504; 0371-53666720 15239990227
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Products Intro:Product Name:Pyrene
CAS:129-00-0
Purity:98% Package:100g;200g;1kg;5kg

Lastest Price from Pyrene manufacturers

  • Pyrene
  • US $1.00 / KG
  • 2018-08-11
  • CAS:129-00-0
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 1
Pyrene Basic information
Coal-tar chemical industrial products Probing agent for determination of the fluidity of membrane lipid Chemical Properties Uses Production method
Product Name:Pyrene
Synonyms:Pyrene (purity);Pyrenepract;PYRENE, FOR FLUORESCENCE;PYRENE, 1X1ML, CH2CL2, 200UG/ML;41164, Pyrene (purity);PYRENE, 5000MG, NEAT;PYRENE-D10, 25MG, NEAT;PYRENE, 1X1ML, MEOH, 1000UG/ML
CAS:129-00-0
MF:C16H10
MW:202.25
EINECS:204-927-3
Product Categories:Aromatic Compounds;Organics;Pyrenes;PAH
Mol File:129-00-0.mol
Pyrene Structure
Pyrene Chemical Properties
Melting point 148 °C
Boiling point 393 °C
density 1.271
refractive index 1.8520 (estimate)
Fp 210 °C
storage temp. APPROX 4°C
solubility ethanol: soluble
form crystalline
color Pale yellow to yellow-greenish
Water Solubility almost insoluble
λmax330nm(EtOH)(lit.)
Merck 14,7963
BRN 1307225
CAS DataBase Reference129-00-0(CAS DataBase Reference)
NIST Chemistry ReferencePyrene(129-00-0)
EPA Substance Registry SystemPyrene(129-00-0)
Safety Information
Hazard Codes N,T+,T,F,Xn
Risk Statements 50/53-36/37/38-26-39/23/24/25-23/24/25-11-63-43-45-67-65-38-51/53-52/53-40
Safety Statements 60-61-45-36/37-28A-22-16-7-24/25-23-53-62-26
RIDADR UN 3077 9/PG 3
WGK Germany 2
RTECS UR2450000
TSCA Yes
HazardClass 6.1(b)
PackingGroup III
Hazardous Substances Data129-00-0(Hazardous Substances Data)
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
Pyrene Usage And Synthesis
Coal-tar chemical industrial productsPyrene is one of the processing products of coal tar with the content in the coal tar being about 0.6 to 1.2% and is mainly concentrated in the anthracene oil fraction. Pyrene is a kind of solid aromatic compound with its molecule comprising of four benzene rings connected with each other. Pyrene has its molecular formula of C16H10, molecular weight of 202.26, melting point of 150 °C, boiling point of 393 °C and the density of 1.277g/cm3. Pyrene appears as pale yellow crystalline monoclinic tablets, insoluble in water and easily soluble in benzene, toluene, carbon disulfide, ether and other organic solvents. Pyrene is carcinogenic and can be converted to mutagenic 1-nitro-pyrene under the effect of nitrogen dioxide. The position 1 and position 6 of pyrene can easily react with electrophilic reagent as well as have oxidation and hydrogenation reaction. Pyrene can also have halogenation, nitration and sulfonation; mono-substitution occurs at the 3-position, di-substitution includes 3, 10 and 3, 8-position with 3, 10 being more frequent. Its oxidation can generate 3, 10-quinones and 3, 8-quinones which can further oxidized to generate 1, 4, 5, 8-naphthalene tetracarboxylic acid.
Pyrene can be used in the production of dyes such as indanthrone dyes and anthraquinone vat dyes. The extraction method of is: take the residuum or bitumen distillate oil produced from the distillation of the anthracene fractions as the raw material, perform distillation under reduced pressure, take the 390~400 ℃ fraction which contains about 40% of pyrene fraction, then use 25% of the coal tar solvent oil and 75% ethanol mixed solvent (the volume of the solvent: pyrene fraction: 1:12), and recrystallized for several times until qualified products are obtained.

Pyrene belongs to low toxicity compounds and has mild irritation effect on the skin, eyes and upper respiratory tract. Long-term inhalation can cause aglobulism and mild liver and kidney damage. Long-term exposure upon 3mg/m3~5mg/m3 can cause headaches, fatigue, loss of appetite, and being prone to excitable.
The above information is edited by the chemicalbook of Dai Xiongfeng.
Probing agent for determination of the fluidity of membrane lipidPyrene is a commonly used probe for determination of the fluidity of the membrane lipid with high quantum yield but shorter excited lifetime than DPH (1, 6-diphenyl a 1, 3, 5-triene), so it is not sensitive enough for determination of the slight change in the lipid fluidity and is suitable for system of greater mobility. The excitation wavelength of pyrene is 342nm and the emission wavelength is 383nm with the excitation and emission spectra overlapping significantly with each other. Pyrene mainly bound to the hydrocarbon chain of the membrane lipid. Once a monomer formed via the binding between a pyrene molecule to lipid molecule had been excited by light, it move and be close to another pyrene molecule which has not been excited yet via lateral diffusion motion, forming collision compounds namely excitation dimer. The efficiency for the formation of the excitation dimer depends on the concentration of pyrene binding to the membrane lipid as well as the viscosity of the medium surrounding the pyrene. When the concentration and temperature of pyrene becomes stable, the ratio of the fluorescence intensity between monomer and dimer will decrease with the increasing viscosity of the medium surrounding the pyrene, namely pyrene, based on the ratio of the fluorescence of dimer to monomer, can reflect the lateral diffusion rate of the lipid molecule. High medium viscosity will cause small lateral diffusion rate and small liquidity.
Reference: Editor: Huishan Liu, Binxue Liu & Zedai Fang; Reviwer: Shuyun Xu & Chuanggeng Ma; English-Chinese dictionary of pharmacology.
Chemical PropertiesIt appears as light yellow monoclinic crystal. It is insoluble in water, easily soluble in ether, carbon disulfide, benzene and toluene.
UsesIt can be used as raw material of organic synthesis. For example, it can be used for production of 1, 4, 5, 8-naphthalene tetracarboxylic acid via oxidation. It can be applied to dyes, synthetic resins and plastics; it can also be used for the manufacturing of vat dye Brilliant Orange GR and various kinds of other dyes. Moreover, it can also be used for the manufacturing of pesticides and plasticizers.
Production methodPyrene is mainly presented in the distillates of coal tar pitch. Send the asphalt for vacuum distillation under medium temperature; at the same time, directly send a small amount of the overheated steam to the distillation vessel; take the narrow fraction of pyrene and then use the mixed solution of solvent oil and ethanol or a mixed solution of benzene and solvent oil for recrystallization to obtain industrial pyrene with purity of 95%.
Chemical Propertiespale yellow to yellow-greenish crystals or chunks
UsesPyrene occurs in coal tar. Also obtained by the destructive hydrogenation of hard coal. Found in wastewater in aquatic environments, and possesses genotoxic characteristics relating to estrogenic/andr ogenic, antiestrogenic and antiandrogenic activity.
General DescriptionColorless solid, solid and solutions have a slight blue fluorescence. Used in biochemical research.
Air & Water ReactionsInsoluble in water.
Reactivity ProfilePyrene reacts with nitrogen oxides to form nitro derivatives. Pyrene also reacts with 70% nitric acid.
Health HazardPyrene is a carcinogenic agent and is absorbed by the skin. It is a skin irritant, a suspected mutagen, and an equivocal tumor-causing agent. Workers exposed to 3 to 5 mg/m3 of Pyrene exhibited some teratogenic effects. Pyrene is a polycyclic aromatic hydrocarbon (PAH). The acute toxicity of pure PAHs appears low when administered orally or dermally to rats or mice. Human exposure to PAHs is almost exclusively via the gastrointestinal and respiratory tracts, and approximately 99 percent is ingested in the diet. Despite the high concentrations of Pyrene to which humans may be exposed through food, there is currently little information available to implicate diet-derived PAHs as the cause of serious health effects.
Fire HazardWhen heated to decomposition, Pyrene emits acrid smoke and fumes.
Purification MethodsCrystallise pyrene from EtOH, glacial acetic acid, *benzene or toluene. Purify it also by chromatography of CCl4 solutions on alumina, with *benzene or n-hexane as eluent. [Backer & Whitten J Phys Chem 91 865 1987.] It can also be zone refined and purified by sublimation. Marvel and Anderson [J Am Chem Soc 76 5434 1954] refluxed pyrene (35g) in toluene (400mL) with maleic anhydride (5g) for 4days, then added 150mL of aqueous 5% KOH and refluxed for 5hours with occasional shaking. The toluene layer was separated, washed thoroughly with H2O, concentrated to about 100mL and allowed to cool. Crystalline pyrene was filtered off and recrystallised three times from EtOH or acetonitrile. [Chu & Thomas J Am Chem Soc 108 6270 1986, Russell et al. Anal Chem 50 2961 1986.] The material is free from anthracene derivatives. Another purification step involves passage of pyrene in cyclohexane through a column of silica gel. It can be sublimed in a vacuum and zone refined. The picrate has m 224o. [Kano et al. J Phys Chem 89 3748 1985, Beilstein 5 IV 2467.]
Pyrene Preparation Products And Raw materials
Raw materialsASPHALTUM-->Medium temperature pitch
Preparation Products1-Aminopyrene-->1-PYRENEDECANOIC ACID-->1-PYRENEBUTYRIC ACID-->1-PYRENECARBOXYLIC ACID
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