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Methicillin Sodium Salt

Methicillin Sodium Salt Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
Email: info@tianfuchem.com
Products Intro: Product Name:TIANFU-CHEM -sodium 6-(2,6-dimethoxybenzamido)penicillanate
CAS:132-92-3
Purity:99% Package:25KG;5KG;1KG
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-029-81138252 +86-18789408387
Email: 1057@dideu.com
Products Intro: Product Name:MethicillinSodium
CAS:132-92-3
Purity:99% Package:1KG;1USD
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Methicillin sodium salt;Meticillin sodium;Methicillin sodium
CAS:132-92-3
Package:1 mL * 10mM (in DMSO);5 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 15093356674;
Email: laboratory@coreychem.com
Products Intro: Product Name:Methicillin Sodium Salt
CAS:132-92-3
Purity:98% Summer 163 Package:1g;9.9USD
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:Methicillin sodium
CAS:132-92-3
Purity:111899% Package:10kg 25kg 200 kilograms per barrel Remarks:good

Methicillin Sodium Salt manufacturers

  • MethicillinSodium
  • MethicillinSodium  pictures
  • $1.00 / 1KG
  • 2020-05-12
  • CAS: 132-92-3
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 20T
Methicillin Sodium Salt Basic information
Product Name:Methicillin Sodium Salt
Synonyms:Methicillin sodium salt;Sodium (2,6-dimethoxyphenyl)penicillin, Sodium methicillin;(2S,5R,6R)-6-[(2,6-Dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt;6α-[(2,6-Dimethoxybenzoyl)amino]penicillanic acid sodium salt;Sodium (2,6-dimethoxyphenyl)penicillin;Sodium methicillin;Meticillin sodium salt;meticillin sodium
CAS:132-92-3
MF:C17H19N2NaO6S
MW:402.39733
EINECS:205-083-9
Product Categories:Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;STAPHCILLIN
Mol File:132-92-3.mol
Methicillin Sodium Salt Structure
Methicillin Sodium Salt Chemical Properties
Melting point 196-197℃
Boiling point 640℃
Fp >110°(230°F)
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form powder
color white to off-white
Water Solubility Slightly soluble in acetone. Soluble in ethanol or water
Sensitive Light Sensitive
Safety Information
Hazard Codes Xn
Risk Statements 36/37/38-42/43
Safety Statements 26-36
WGK Germany 2
RTECS XH8950000
ToxicityLD50 oral in mouse: > 4gm/kg
MSDS Information
Methicillin Sodium Salt Usage And Synthesis
DescriptionMethicillin is a semisynthetic penicillin antibiotic that can inhibit bacterial cell wall synthesis. It can be used to study methicillin-resistance in S. aureus.
Usesantibacterial
UsesSemi-synthetic antibiotic related to Penicillin. Antimicrobial.
UsesTargets primarily the cell wall of Gram-positive organisms especially Staphylococcus aureus. Methicillin is used to study bacterium susceptibility, and to inhibit cell-wall synthesis. PBP's are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Methicillin Sodium Salt is inactivated by gastric acid so it is given to cells by other means in which gastric acid is not present in vitro.
DefinitionChEBI: Methicillin sodium is an organic sodium salt. It contains a methicillin(1-).
Brand nameStaphcillin (Apothecon).
Clinical UseDuring 1960, methicillin sodium, 2,6-dimethoxyphenylpenicillinsodium (Staphcillin), the second penicillin produced asa result of the research that developed synthetic analogs, wasintroduced for medicinal use.
Methicillin sodium is particularly resistant to inactivationby the penicillinase found in staphylococci and somewhatmore resistant than penicillin G to penicillinase fromBacillus cereus.
in vitrosimilar to other β-lactam antibiotics, meticillin acts via inhibiting the synthesis of bacterial cell walls. meticillin can block the cross-linkage between the linear peptidoglycan polymer chains by binding to and competitively inhibiting the transpeptidase enzyme or penicillin-binding proteins [1].
in vivoin a previous animal study, the treatment with methicillin or gentamicin or both was started 3 days after infection to a experimental mouse model of foreign body infection. results found that the treatment showed a significant effect, demonstrated as reduction of bacteria on the foreign body, for all three regimens with a reduction of up to 2 log units, but there was no synergism. however, the actual efficacy of the treatment was poor, though the local methicillin concentrations was greater than the mic for at least 72 h [2].
references[1] https://en. wikipedia.org/wiki/meticillin
[2] espersen f, frimodt-m ller n, corneliussen l, riber u, rosdahl vt, skinh j p. effect of treatment with methicillin and gentamicin in a new experimental mouse model of foreign body infection. antimicrob agents chemother. 1994 sep;38(9):2047-53.
Methicillin Sodium Salt Preparation Products And Raw materials
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