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Benzo[b]thiophene-2-butanoic acid, 5,5'-(1,3-propanediyl)bis[6-methoxy-γ-oxo-

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Benzo[b]thiophene-2-butanoic acid, 5,5'-(1,3-propanediyl)bis[6-methoxy-γ-oxo- Suppliers list
Company Name: Aladdin Scientific
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Products Intro: Product Name:MSA-2 dimer
CAS:2377881-92-8
Purity:99% Package:$850.9/5mg;$1350.9/10mg;Bulk package Remarks:99%
Company Name: TargetMol Chemicals Inc.  
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Products Intro: Product Name:MSA-2 dimer;MSA 2 dimer,MSA2 dimer
CAS:2377881-92-8
Purity:98% Package:10 mg;5 mg
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Tel: 0513-66337626 18051384581
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Products Intro: Product Name:MSA-2 dimer
CAS:2377881-92-8
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10g，more
Company Name: Shanghai?Medlife?Pharm-Tech?Co.,?Ltd  
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Products Intro: Product Name:MSA-2 dimer
CAS:2377881-92-8
Purity:>=99% Package:5mg;10mg;50mg;100mg
Benzo[b]thiophene-2-butanoic acid, 5,5'-(1,3-propanediyl)bis[6-methoxy-γ-oxo- Basic information
Product Name:Benzo[b]thiophene-2-butanoic acid, 5,5'-(1,3-propanediyl)bis[6-methoxy-γ-oxo-
Synonyms:MSA-2 dimer;Benzo[b]thiophene-2-butanoic acid, 5,5'-(1,3-propanediyl)bis[6-methoxy-γ-oxo-;MSA 2 dimer,MSA2 dimer
CAS:2377881-92-8
MF:C29H28O8S2
MW:568.66
EINECS:
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Mol File:2377881-92-8.mol
Benzo[b]thiophene-2-butanoic acid, 5,5'-(1,3-propanediyl)bis[6-methoxy-γ-oxo- Structure
Benzo[b]thiophene-2-butanoic acid, 5,5'-(1,3-propanediyl)bis[6-methoxy-γ-oxo- Chemical Properties
Boiling point 817.6±65.0 °C(Predicted)
density 1.376±0.06 g/cm3(Predicted)
pka4.10±0.17(Predicted)
Safety Information
MSDS Information
Benzo[b]thiophene-2-butanoic acid, 5,5'-(1,3-propanediyl)bis[6-methoxy-γ-oxo- Usage And Synthesis
Biological ActivityMSA-2 dimer is a selective, orally active non-nucleotide STING agonist (Kd=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide[1]. MSA-2 dimer (60 mg/kg; p.o.; 50 days) inhibits tumor growth and prolongs overall survival[1]. MSA-2 dimer (40 mg/kg; s.c.; 25 days) induces complete tumor regression[1].MSA-2 dimer (60 mg/kg; p.o.; 4 hours) increases proinflammatory cytokine (IFN-β) level in tumors[1].MSA-2 dimer (60 mg/kg; s.c.; 4 hours) concentrations is observed in tumors than in plasma or other nontumor tissues [1].MSA-2 dimer (THP-1 cells) induces phosphorylation of both TBK1 and IR. MSA-2 dimer (10 μM and 33 μM; macrophages) induces IFN-β[1].MSA-2 dimer also exhibits dose-dependent antitumor activity when administered by IT, SC, or PO routes[1].
References[1]. Pan BS, et al. An orally available non-nucleotide STING agonist with antitumor activity. Science. 2020;369(6506):eaba6098.
Benzo[b]thiophene-2-butanoic acid, 5,5'-(1,3-propanediyl)bis[6-methoxy-γ-oxo- Preparation Products And Raw materials
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