cGAMP disodium manufacturers
- cGAMP disodium
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- $2128.00 / 5mg
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2025-09-22
- CAS:2407516-83-8
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | cGAMP disodium Basic information |
| Product Name: | cGAMP disodium | | Synonyms: | cGAMP disodium;3',3'-cGAMP disodium);cGAMP disodium (Cyclic GMP-AMP disodium;3',3'-cGAMP disodium | | CAS: | 2407516-83-8 | | MF: | C20H25N10NaO13P2 | | MW: | 698.41 | | EINECS: | | | Product Categories: | | | Mol File: | 2407516-83-8.mol |  |
| | cGAMP disodium Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Water: 10 mM | | form | Solid | | color | White to off-white | | Water Solubility | Soluble to 10 mM in water |
| | cGAMP disodium Usage And Synthesis |
| Uses | cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4]. | | Biological Activity | cGAMP disodium (Cyclic GMP-AMP disodium) is the third cyclic dinucleotide (CDN) to be discovered in bacteria. cGAMP disodium is an effective adjuvant for sublingual vaccination capable of promoting broad immunity including serum anti-PA neutralizing and anti-PA SIgA responses in airway secretions[1][2]. | | in vivo | cGAMP (5 μg; nostril mucosal adjuvant) disodium promotes the antigen-specific cytokine production by spleen cells of immunized mice[2]. | Animal Model: | Female C57BL/6 (H-2b) mice 6-8 weeks old[2] | | Dosage: | 5 μg | | Administration: | Nostril mucosal adjuvant | | Result: | Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice.
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| | IC 50 | Human Endogenous Metabolite | | storage | Store at -20°C | | References | [1] Wright TA, et al. Second messengers and divergent HD - GYP phosphodiesterases regulate 3’,3’ - cGAMP signaling. Mol Microbiol. 2020;113(1):222 - 236.
[2] BRYAN W DAVIES. Coordinated regulation of accessory genetic elements produces cyclic di - nucleotides for V. cholerae virulence.[J]. Cell, 2012, 149 2: 358 - 370. DOI: 10.1016/j.cell.2012.01.053
[3] XU ZHANG. Cyclic GMP - AMP containing mixed phosphodiester linkages is an endogenous high - affinity ligand for STING.[J]. Molecular Cell, 2013, 51 2: 226 - 235. DOI: 10.1016/j.molcel.2013.05.022 |
| | cGAMP disodium Preparation Products And Raw materials |
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