| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
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| Tel: |
021-61312847; 18021002903 |
| Email: |
3008007409@qq.com |
| Products Intro: |
Product Name:HPPE
CAS:1325721-55-8
Purity:98% Package:5mg Remarks:S89912
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| Company Name: |
Shanghai Chaolan Chemical Technology Center
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| Tel: |
021-QQ：65489617 15618227136 |
| Email: |
Sales@ATKchemical.com |
| Products Intro: |
Product Name:1H-Benzimidazole-5-carboxamide, N-[2-(2-hydroxyethoxy)ethyl]-1-methyl-2-[[6-(trifluoromethyl)-2-benzothiazolyl]amino]-
CAS:1325721-55-8
Purity:98 Package:1G,5G,10G,50G,100G,500G
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| Company Name: |
Changzhou Chenhong Biotechnology Co., Ltd.
|
| Tel: |
+86-0519-85788828 +86-13775037613 |
| Email: |
sales@chemrenpharm.com |
| Products Intro: |
Product Name:HPPE
CAS:1325721-55-8
Purity:99% Package:50mg;100mg;250mg;500mg;1g;5g
|
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| | 1H-Benzimidazole-5-carboxamide, N-[2-(2-hydroxyethoxy)ethyl]-1-methyl-2-[[6-(trifluoromethyl)-2-benzothiazolyl]amino]- Basic information |
| | 1H-Benzimidazole-5-carboxamide, N-[2-(2-hydroxyethoxy)ethyl]-1-methyl-2-[[6-(trifluoromethyl)-2-benzothiazolyl]amino]- Chemical Properties |
| density | 1.52±0.1 g/cm3(Predicted) | | pka | 13.27±0.46(Predicted) | | form | Solid | | color | White to off-white |
| | 1H-Benzimidazole-5-carboxamide, N-[2-(2-hydroxyethoxy)ethyl]-1-methyl-2-[[6-(trifluoromethyl)-2-benzothiazolyl]amino]- Usage And Synthesis |
| Uses | HPPE (compound 236) is an orally active, potential Bach1 inhibitor. Bach1 is a transcription factor of the cap'n'collar type alkaline region leucine zipper factor family (CNC-bZip) that regulates mitochondrial metabolism and reduces glucose utilization. HPPE can be used for research in psoriasis, multiple sclerosis, and COPD[1][2][3][4]. | | in vivo | HPPE (5 and 10 mg/kg, oral gavage, twice a day for 6 days) ameliorates MPTP-induced dopaminergic neurodegeneration and associated oxidative stress and neuroinflammation in the acute MPTP mouse model[3].
| Animal Model: | The acute MPTP mouse model[2] | | Dosage: | 5 and 10 mg/kg | | Administration: | oral gavage, twice a day for 6 days | | Result: | Significantly protected SNpc dopaminergic neurons against MPTP neurotoxicity. |
| | References | [1] Attucks, et al. Bach 1 inhibitors in combination with Nrf2 activators and pharmaceutical compositions thereof. World Intellectual Property Organization, WO2016089648 A1 2016-06-09.
[2] Zhang X, et al. Bach1: Function, Regulation, and Involvement in Disease. Oxid Med Cell Longev. 2018 Oct 2;2018:1347969. DOI:10.1155/2018/1347969
[3] Ahuja M, et al. Bach1 derepression is neuroprotective in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A. 2021 Nov 9;118(45):e2111643118. DOI:10.1073/pnas.2111643118
[4] Freeman R, et al. HPPE Activates NRF2 Signaling by Liberating Heavy Metal Stores. Chembiochem. 2024 Sep 6:e202400529. DOI:10.1002/cbic.202400529 |
| | 1H-Benzimidazole-5-carboxamide, N-[2-(2-hydroxyethoxy)ethyl]-1-methyl-2-[[6-(trifluoromethyl)-2-benzothiazolyl]amino]- Preparation Products And Raw materials |
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