|
|
| | LEVCROMAKALIM Basic information |
| Product Name: | LEVCROMAKALIM | | Synonyms: | (3S,4R)-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-4-(2-OXO-1-PYRROLIDINYL)-2H-1-BENZOPYRAN-6-CARBONITRILE;(3s-trans)-yrrolidinyl);LEVCROMAKALIM;2h-1-benzopyran-6-carbonitrile,3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-p;brl38227;lemakalim;levcromakelim;(3S,4R)-3β-Hydroxy-4-(2-oxopyrrolizino)-2,2-dimethyl-3,4-dihydro-6-cyano-2H-1-benzopyran | | CAS: | 94535-50-9 | | MF: | C16H18N2O3 | | MW: | 286.33 | | EINECS: | | | Product Categories: | | | Mol File: | 94535-50-9.mol |  |
| | LEVCROMAKALIM Chemical Properties |
| Melting point | 242-244° | | alpha | D26 -52.2° (c = 1 in chloroform) | | Boiling point | 482.3±45.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | DMSO: ≤10 mM, soluble | | pka | 13.18±0.60(Predicted) | | form | solid |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | DJ2177500 |
| | LEVCROMAKALIM Usage And Synthesis |
| Uses | Anti-asthmatic; antihypertensive. | | Uses | Levcromakalim is a potassium channel activator and vasorelaxant used in the management of hypertension in diabetes mellitus. | | Definition | ChEBI: Levcromakalim is a 1-benzopyran. | | Biological Activity | Active enantiomer of the prototypical K ATP channel opener cromakalim (trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile ). Hypotensive and airways relaxant. IC 50 = 490 nM in guinea pig trachea. | | storage | Store at RT |
| | LEVCROMAKALIM Preparation Products And Raw materials |
|