吡罗达韦
中文名称 | 吡罗达韦 |
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中文同义词 | 吡罗达韦;4-(2-(1-(6-甲基哒嗪-3-基)哌啶-4-基)乙氧基)苯甲酸乙酯;R77975|||吡罗达韦 |
英文名称 | pirodavir |
英文同义词 | Ethyl 4-[2-[1-(6-methyl-3-pyridazinyl)-4-piperidinyl]ethoxy]benzoate;pirodavir(R 77975);R 77975, Pirodavir;pirodavi;pirodavir;Pirodavir, >=99%;Ethyl 4-(2-(1-(6-methylpyridazin-3-yl)piperidin-4-yl)ethoxy)benzoate;Ethyl p-[2-[1-(6-Methylpyridazin-3-yl)piperidin-4-yl]-ethoxy]benzoate |
CAS号 | 124436-59-5 |
分子式 | C21H27N3O3 |
分子量 | 369.46 |
EINECS号 | |
相关类别 | 小分子抑制剂,天然产物;小分子抑制剂;Inhibitors |
Mol文件 | 124436-59-5.mol |
结构式 |
吡罗达韦 性质
熔点 | 124-125℃ |
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储存条件 | Sealed in dry,Store in freezer, under -20°C |
溶解度 | 可溶于氯仿(少许)、DMSO(少许)、甲醇(少许) |
形态 | 固体 |
颜色 | 灰白色至浅米色 |
Rhinovirus
Pirodavir is a potent, broad-spectrum picornavirus inhibitor. Pirodavir inhibits 80 of the 100 human rhinovirus (HRV) strains tested at a concentration of 64 ng/mL. In that same study, Pirodavir is also effective in inhibiting 16 enteroviruses, with a mean 80% inhibitory concentration (IC 80 ) of 1,300 ng/mL. Pirodavir inhibits enterovirus 71 replication with an IC 50 of 5,420 nM and an IC 90 of >13,350 nM. Pirodavir inhibits 56 rhinovirus laboratory strains and three of the clinical isolates tested. Pirodavir inhibits 59% of the serotypes and isolates with IC 50 s of <100 nM. Pirodavir concentrations of 16 and 4μg/mL reduces cell growth by 66% (s.e.m. 0.75) and 28% (s.e.m. 0.25), respectively. Lower concentrations (1μg/mL) of Pirodavir are not inhibitory for cell growth. The 50% cytotoxic concentration of pirodavir for logarithmic cell growth at 37°C is 7μg/mL. Under the conditions of the antiviral assay (confluent HeLa cells at 33°C), the 50% cytotoxic concentration is >50μg/mL.
安全信息
海关编码 | 2933.99.7500 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-13784 | 吡罗达韦 Pirodavir | 124436-59-5 | 2mg | 970元 |
2024/08/19 | HY-13784 | 吡罗达韦 Pirodavir | 124436-59-5 | 5mg | 1900元 |