ANTI-HUMAN DNA TOPOISOMERASE I

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ANTI-HUMAN DNA TOPOISOMERASE I Suppliers list
Company Name: Merck KGaA  
Tel: 21-20338288
Email: ordercn@merckgroup.com
Company Name: Riedel-de Haen AG  
Tel: 800 558-9160
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Company Name: BD Biosciences  
Tel: 1 877 232 8995 U.S. orders
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ANTI-HUMAN DNA TOPOISOMERASE I Basic information
Product Name:ANTI-HUMAN DNA TOPOISOMERASE I
Synonyms:Anti-TOP1 antibody produced in rabbit;ANTI-DNA TOPOISOMERASE I;ANTI-HUMAN DNA TOPOISOMERASE I;Anti-DNA topoisomerase 1
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MW:0
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Mol File:Mol File
ANTI-HUMAN DNA TOPOISOMERASE I Structure
ANTI-HUMAN DNA TOPOISOMERASE I Chemical Properties
storage temp. -20°C
form buffered aqueous glycerol solution
biological sourcerabbit
Safety Information
WGK Germany WGK 1
Storage Class10 - Combustible liquids
MSDS Information
ANTI-HUMAN DNA TOPOISOMERASE I Usage And Synthesis
Biological ActivityDNA topoisomerases cause single (type-1) or double (type-2) strand DNA breaks, leading to DNA relaxation. They control DNA replication, transcription, recombination and chromatin remodeling. TOP1 (DNA topoisomerase 1) binding to the promoter areas induces nucleosome disassembly, histone acetylation and gene expression. Camptothecin is a non-competitive TOP1 inhibitor. TOP1 also controls alternative splicing through phosphorylation of serine/arginine-rich proteins. It is up-regulated in non-small cell lung cancer (NSCLC).
ANTI-HUMAN DNA TOPOISOMERASE I Preparation Products And Raw materials
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TOPOISOMERASE I