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| | Fentonium Basic information |
| Product Name: | Fentonium | | Synonyms: | Fentonium;FA-402;Ketoscilium;Phentonium;Ulcesium;Z-326;[8-methyl-8-[2-oxo-2-(4-phenylphenyl)ethyl]-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate bromide;[8-methyl-8-[2-oxo-2-(4-phenylphenyl)ethyl]-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenyl-propanoate bromide | | CAS: | 5868-06-4 | | MF: | C31H34BrNO4 | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | 5868-06-4.mol |  |
| | Fentonium Chemical Properties |
| Melting point | 203-205° (dec); mp 193-194° | | alpha | D23 -5.68° (c = 5 in DMF); D25 -4.7° (c = 5 in DMF) |
| Toxicity | LD50 in mice (mg/kg): 12.1 i.v.; >400 s.c. and orally (Teotino, Della Bella) |
| | Fentonium Usage And Synthesis |
| Originator | Hoelcesium,Zambon,Italy | | Manufacturing Process | 5.50g (0.02 mol) of p-phenylphenacyl bromide were dissolved in 56 cc of
anhydrous acetone previously heated to about 40°C. This solution was added,
with stirring, to a solution of 5.70 g (0.02 mol) of 1-hyoscyamine in 43 cc of
anhydrous acetone; the reaction solution was maintained at 45°C and stirred
for about six hours.
After standing overnight in the refrigerator, the precipitate was collected by
filtration and dried in vacuo at 60°C. Yield: 10.2 g; MP = 193°C to 194°C. | | Therapeutic Function | Anticholinergic, Spasmolytic |
| | Fentonium Preparation Products And Raw materials |
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