| Company Name: |
Nantong Hi-Future Biotechnology Co., Ltd
|
| Tel: |
18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:PROTAC AR-V7 degrader-1
CAS:2767440-24-2
Purity:98%HPLC Package:10mg，100mg，500mg，1g，2g，5g，10g，more
|
| Company Name: |
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
|
| Tel: |
021-59167510 18117107507 |
| Email: |
vip@med-life.cn |
| Products Intro: |
Product Name:PROTAC AR-V7 degrader-1
CAS:2767440-24-2
Purity:>=99% Package:50mg;100mg;10mM*1mLinDMSO;5mg;10mg
|
|
| | PROTAC AR-V7 degrader-1 Basic information |
| | PROTAC AR-V7 degrader-1 Chemical Properties |
| density | 1.262±0.06 g/cm3(Predicted) | | pka | 13.97±0.40(Predicted) | | form | Solid | | color | White to off-white |
| | PROTAC AR-V7 degrader-1 Usage And Synthesis |
| Uses | PROTAC AR-V7 degrader-1 (Compound 6) is a potent, orally bioavailable and selective AR-V7 degrader with the DC50 of 0.32 μM by recruiting VHL E3 ligase to Androgen receptor (AR) DNA binding domain (DBD) binder. PROTAC AR-V7 degrader-1 exhibits activity against 22Rv1 cell-line expressing AR-V7 with the EC50 of 0.88 μM[1]. | | IC 50 | VHL | | References | [1] Archana Bhumireddy,?et al. Design, synthesis, and biological evaluation of phenyl thiazole-based AR-V7 degraders. Bioorg Med Chem Lett.?2022 Jan 1;55:128448. DOI:10.1016/j.bmcl.2021.128448 |
| | PROTAC AR-V7 degrader-1 Preparation Products And Raw materials |
|