| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Multi-kinase-IN-3
CAS:2091950-43-3
Package:25mg/RMB 10600;50mg/RMB 13800;100mg/RMB 17500
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1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[2-[(4-methyl-1-piperazinyl)methyl]-1H-pyrrol-1-yl]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)- manufacturers
- Multi-kinase-IN-3
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- $1520.00 / 25mg
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2025-04-30
- CAS:2091950-43-3
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[2-[(4-methyl-1-piperazinyl)methyl]-1H-pyrrol-1-yl]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)- Basic information |
| | 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[2-[(4-methyl-1-piperazinyl)methyl]-1H-pyrrol-1-yl]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)- Chemical Properties |
| Boiling point | 736.0±60.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | pka | 10.98±0.20(Predicted) |
| | 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[2-[(4-methyl-1-piperazinyl)methyl]-1H-pyrrol-1-yl]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)- Usage And Synthesis |
| Uses | Multi-kinase-IN-3 (compound 2) is a potent angiokinase inhibitor. Multi-kinase-IN-3 shows inhibition activity against VEGFR-2 and PDGFRβ, with IC50 values of 58.3 and 55 nM, respectively[1]. | | IC 50 | PDGFRβ: 55 ± 2.6 nM (IC50); VEGFR-2: 58.3 ± 5.9 nM (IC50) | | References | [1] Qin M, et al. Structural modifications of indolinones bearing a pyrrole moiety and discovery of a multi-kinase inhibitor with potent antitumor activity. Bioorg Med Chem. 2020 Jun 1;28(11):115486. DOI:10.1016/j.bmc.2020.115486 |
| | 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[2-[(4-methyl-1-piperazinyl)methyl]-1H-pyrrol-1-yl]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)- Preparation Products And Raw materials |
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