- 2-Methyl-5-nitropyridine
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- $5.00 / 1KG
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2024-04-08
- CAS:21203-68-9
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: g-kg-tons, free sample is available
- 5-Nitro-2-picoline
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- $0.00 / 25kg
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2024-03-28
- CAS:21203-68-9
- Min. Order: 25kg
- Purity: 98%
- Supply Ability: Inquiry
- 2-Methyl-5-nitropyridine
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- $0.00 / 1Kg/Bag
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2021-09-29
- CAS:21203-68-9
- Min. Order: 1KG
- Purity: 98%min HPLC
- Supply Ability: 100KGS
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| | 2-Methyl-5-nitropyridine Basic information |
| | 2-Methyl-5-nitropyridine Chemical Properties |
| Melting point | 112 C | | Boiling point | 237.1±20.0 °C(Predicted) | | density | 1.246±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 1.92±0.10(Predicted) | | form | Solid | | color | Light yellow to Brown | | Water Solubility | Slightly soluble in water. | | InChI | InChI=1S/C6H6N2O2/c1-5-2-3-6(4-7-5)8(9)10/h2-4H,1H3 | | InChIKey | USZINSZJSVMICC-UHFFFAOYSA-N | | SMILES | C1(C)=NC=C([N+]([O-])=O)C=C1 | | CAS DataBase Reference | 21203-68-9(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | HS Code | 2933399990 |
| | 2-Methyl-5-nitropyridine Usage And Synthesis |
| Uses | 2-Methyl-5-nitropyridine is used as pharmaceutical intermediate. | | Synthesis | 2-(5-nitro-pyridin-2-yl)-malonic acid diethyl ester could be used as a starting material to synthesize 2-methyl-5-nitropyridine. The specific operations are as follows: To 2-(5-nitro-pyridin-2-yl)-malonic acid diethyl ester (12.0 g, 42.5 mmol) was added cold aq. 20% sulfuric acid (120 mL) and the mixture was heated to 100 ℃ for 2h. The cooled reaction was added to a cold dilute sodium hydroxide solution and the pH adjusted to 10. The organics were extracted with dichloromethane (x 4), and then the combined organic phases were dried over sodium sulfate. The filtrate was concentrated to afford 2-methyl-5-nitropyridine (5.0 g, 83 %) as a brown solid.
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| | 2-Methyl-5-nitropyridine Preparation Products And Raw materials |
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