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Product Name:BIRT 377
CAS:213211-10-0
Purity:≥98% by HPLC Remarks:BIRT 377 is a negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) (Kd = 26 nM), which is involved in some important immunological events. BIRT 377 reversibly inhibits LFA
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| | BIRT 377 Basic information |
| Product Name: | BIRT 377 | | Synonyms: | BIRT 377;(5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione;2,4-Imidazolidinedione, 5-[(4-bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-, (5R)- | | CAS: | 213211-10-0 | | MF: | C18H15BrCl2N2O2 | | MW: | 442.13 | | EINECS: | | | Product Categories: | | | Mol File: | 213211-10-0.mol |  |
| | BIRT 377 Chemical Properties |
| Melting point | 135-136 °C | | Boiling point | 518.8±60.0 °C(Predicted) | | density | 1.552±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | -2.21±0.40(Predicted) |
| | BIRT 377 Usage And Synthesis |
| Uses | BIRT 377 inhibits lymphocyte function-associated antigen-1(LFA-1), which is a cell-adhesion molecule that mediates important immunological events (1). BIRT 377 is also a leukocyte adhesion suppressor (1). Studies showed that BIRT 377 inhibits lymphocyte activity both in vitro and in vivo (2) | | storage | Store at +4°C |
| | BIRT 377 Preparation Products And Raw materials |
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