| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:3-[(1,2-Dichlorovinyl)thio]-L-alanine Hydrochloride Salt
CAS:627-72-5
Package:50Mg,5Mg
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| Company Name: |
Chemsky（shanghai）International Co.,Ltd.
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| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:3-[(1,2-Dichlorovinyl)thio]-L-alanine Hydrochloride Salt
CAS:627-72-5
Purity:98%
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
| Products Intro: |
Product Name:3-[(1,2-Dichlorovinyl)thio]-L-alanine
CAS:627-72-5
Purity:NULL Package:50mg;5mg Remarks:NULL
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| Company Name: |
Nanjing Shizhou Biology Technology Co.,Ltd
|
| Tel: |
13675144456 |
| Email: |
alan.chow@synzest.com |
| Products Intro: |
Product Name:S-(1,2-Dichlorovinyl)Cysteine hydrochloride
CAS:627-72-5
Purity:95% HPLC Package:100mg;250mg;500mg;1g;5g Remarks:adventbio
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| | S-(1,2-dichlorovinyl)cysteine Basic information |
| | S-(1,2-dichlorovinyl)cysteine Chemical Properties |
| Melting point | 144-151°C | | Boiling point | 339.7±42.0 °C(Predicted) | | density | 1.437 (estimate) | | refractive index | 1.6100 (estimate) | | storage temp. | -20°C Freezer, Under Inert Atmosphere | | solubility | Methanol | | pka | 1.82±0.10(Predicted) | | form | Solid | | color | Tan |
| | S-(1,2-dichlorovinyl)cysteine Usage And Synthesis |
| Uses | Hydrochloride salt of 3-[(1,2-Dichlorovinyl)thio]-L-alanine, a mutagenic and nephrotoxic metabolite of trichloroethylene. | | Uses | S-(1,2-Dichlorovinyl)-L-cysteine (DCVC) is a model nephrotoxicant
and cataractogen used to induce acute renal failure
and cataracts in experimental animals to study the biochemical,
physiological, and molecular mechanisms underlying the
disease. | | Definition | ChEBI: An L-alpha-amino acid that is L-cysteine in which the hydrogen attached to the sulfur is replaced by a 1,2-dichlorovinyl group. | | Environmental Fate | Human exposure to DCVC occurs only via potential formation
of DCVC in vivo following trichloroethylene (TCE) exposure;
therefore, no data are available in this regard. | | Toxicity evaluation | Cell death is initiated by the metabolism of DCVC via renal
cysteine conjugate b-lyase to a sulfur-containing reactive thiol
radical that covalently binds to macromolecules.
The findings that the nephrotoxicity and cataractogenesis of
DCVC can be blocked by aminooxyacetic acid (a selective
inhibitor of b-lyase) and probenecid (organic anion transport
Encyclopedia of inhibitor) provide evidence for the roles of cysteine conjugate
b-lyase and the organic anion transport system, respectively,
in DCVC-induced nephrotoxicity. Although the b-lyase
enzyme is considered to be the major bioactivating enzyme
for DCVC, other bioactivating enzyme activities
have been described, and some of these may have relevance to
risk assessment. Studies have shown that renal FMO3 can also
metabolize DCVC to form DCVC sulfoxide thereby causing
nephrotoxicity. Reports from several laboratories indicate that
the cytotoxicity of DCVC is mediated at the mitochondrial
level. Depletion of GSH, mitochondrial lipid peroxidation
and GSSG formation, inhibition of mitochondrial
lipoyl dehydrogenase activity, release of Ca2+ from mitochondria,
and inhibition of mitochondrial membrane
potential have been observed prior to renal cell death and
correlated well with cytotoxicity. |
| | S-(1,2-dichlorovinyl)cysteine Preparation Products And Raw materials |
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