化合物SB 204990
中文名称 | 化合物SB 204990 |
---|---|
中文同义词 | 化合物SB 204990;SB-204990(消旋);SB 204990,ATP柠檬酸裂解酶(ACLY)抑制剂;2-((3S,5R)-5-(6-(2,4-二氯苯基)己基)-3-羟基-2-氧代四氢呋喃-3-基)乙酸 |
英文名称 | SB 204990 |
英文同义词 | SB 204990;3-Furanacetic acid, 5-[6-(2,4-dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-, (3R,5S)-rel-;2-((3R,5S)-5-(6-(2,4-dichlorophenyl)hexyl)-3-hydroxy-2-oxotetrahydrofuran-3-yl)acetic acid;(3R,5S)-rel-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid;YTRNLFYTHYWDAU-KDOFPFPSSA-N;SB-204990(racemic);SB204990,Inhibitor,inhibit,ACLY,SB 204990,ATP Citrate Lyase,SB-204990;2-((3S,5R)-5-(6-(2,4-Dichlorophenyl)hexyl)-3-hydroxy-2-oxotetrahydrofuran-3-yl)acetic acid |
CAS号 | 154566-12-8 |
分子式 | C18H22Cl2O5 |
分子量 | 389.27 |
EINECS号 | |
相关类别 | 化学试剂 |
Mol文件 | 154566-12-8.mol |
结构式 |
化合物SB 204990 性质
熔点 | 87-89 °C |
---|---|
沸点 | 571.6±40.0 °C(Predicted) |
密度 | 1.332±0.06 g/cm3(Predicted) |
溶解度 | DMF:30mg/mL; DMF:PBS(pH7.2)(1:2):0.33mg/ml; DMSO:20mg/mL;乙醇:1mg/mL |
形态 | 结晶固体 |
酸度系数(pKa) | 4.33±0.10(Predicted) |
颜色 | 白色至米白色 |
InChI | InChI=1/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,11-16(21)22)17(23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18+/s3 |
InChIKey | YTRNLFYTHYWDAU-RVFWCEGZNA-N |
SMILES | O1[C@@H](CCCCCCC2=CC=C(Cl)C=C2Cl)C[C@@](O)(CC(O)=O)C1=O |&1:1,17,r| |
ACLY.
SB204990 (SB) is a specific inhibitor of ACLY enzyme. SB204990 treatment leads to a decrease in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels.
SB 204990, when administered orally to rats, is absorbed into the systemic circulation. When administered in the diet (0.05-0.25%, w/w) for 1 week, SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-16450 | 化合物SB 204990 SB 204990 | 154566-12-8 | 5mg | 1200元 |
2024/08/19 | HY-16450 | 化合物SB 204990 SB 204990 | 154566-12-8 | 10mM * 1mLin DMSO | 1320元 |