J-1048

J-1048 Suppliers list

Company Name:	TargetMol Chemicals Inc.
Tel:	+17819995354
Email:	marketing@targetmol.com
Products Intro:	Product Name:J-1048 CAS:2374772-60-6 Package:25mg;1520USD\|100mg;2500USD\|50mg;1980USD

Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Email:	marketing@targetmol.cn
Products Intro:	Product Name:J-1048 CAS:2374772-60-6 Package:25mg/RMB 10600;100mg/RMB 17500;50mg/RMB 13800

J-1048 manufacturers

J-1048 Basic information

Product Name:	J-1048
Synonyms:	J-1048;1H-Pyrazole-1-ethanethioamide, 4-(2,1,3-benzothiadiazol-5-yl)-N-(3-fluorophenyl)-3-(6-methyl-2-pyridinyl)-
CAS:	2374772-60-6
MF:	C23H17FN6S2
MW:	460.55
EINECS:
Product Categories:
Mol File:	2374772-60-6.mol

J-1048 Chemical Properties

Melting point	134-136 °C
Boiling point	588.077±60.00 °C(Press: 760.00 Torr)(predicted)
density	1.441±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka	10.312±0.10(predicted)

Safety Information

MSDS Information

J-1048 Usage And Synthesis

Uses	J-1048 is an activin receptor-like kinase 5 (ALK5) inhibitor. J-1048 can inhibit TAA-induced liver fibrosis in mice by explicitly blocking the TGF-β/Smad signaling pathway[1].
References	[1] Yang HX, et al. Synthesis of and anti-fibrotic effect of pyrazole derivative J-1048: Inhibition of ALK5 as a novel approach to liver fibrosis targeting inflammation. Bioorg Chem. 2023 Oct;139:106723. DOI:10.1016/j.bioorg.2023.106723

J-1048 Preparation Products And Raw materials

Tag:J-1048(2374772-60-6) Related Product Information

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