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| | 2,2,2-Trifluoroethyl trifluoromethanesulfonate Basic information |
| Product Name: | 2,2,2-Trifluoroethyl trifluoromethanesulfonate | | Synonyms: | 2,2,2-trifluoroethyltrifluorometanesulfonicacid;methanesulfonicacid,trifluoro-,2,2,2-trifluoroethylester;TRIFLUOROMETHANESULFONIC ACID 2,2,2-TRIFLUOROETHYL ESTER;TFOL-TF;2,2,2-TRIFLUOROETHYL TRIFLUOROMETHANESULFONATE;2,2,2-Trifluoroethyltrifluoromethanesulphonate97%;TRIFLUOROMETHANESULPHONICACID2,2,2-TRIFLUOROETHYLESTER;2,2,2 Trifluoroethyl TrifluoroMathane sulfonate | | CAS: | 6226-25-1 | | MF: | C3H2F6O3S | | MW: | 232.1 | | EINECS: | 458-390-7 | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Synthetic Organic Chemistry;R00001 | | Mol File: | 6226-25-1.mol |  |
| | 2,2,2-Trifluoroethyl trifluoromethanesulfonate Chemical Properties |
| Hazard Codes | Xi,T,C | | Risk Statements | 36/37/38-34-23/25 | | Safety Statements | 26-36/37/39-45 | | RIDADR | 3265 | | WGK Germany | 3 | | Hazard Note | Irritant | | HazardClass | TOXIC, CORROSIVE | | HazardClass | 8 | | PackingGroup | Ⅱ | | HS Code | 29055900 |
| | 2,2,2-Trifluoroethyl trifluoromethanesulfonate Usage And Synthesis |
| Uses | A fluorine-containing alkyl alkanesulfonate with cyctotoxity towards cultured leukemia L1210 cells. | | Uses | 2,2,2-Trifluoroethyl trifluoromethanesulfonate is a powerful trifluoroethylating agent which is useful for synthesis of fluorinated amino acids. It is used as a reagent in thenantioselective preparation of cyclic N-aryl hydroxamic acids via phase-transfer catalyzed alkylation of nitrobenzyl bromides to give nirophenylalanines. | | Uses | Reagent used in thenantioselective preparation of cyclic N-aryl hydroxamic acids via phase-transfer catalyzed alkylation of nitrobenzyl bromides to give nirophenylalanines | | Synthesis | In a 100-ml flask equipped with a stirrer, a thermometer, a nitrogen introducing pipe, and a condenser, 50 ml (0.297 mol) of trifluoromethane sulfonic anhydride and 25 ml (0.342 moles) of 2,2,2-trifluoroethanol were placed at room temperature and stirred for 30 minutes in a nitrogen atmosphere, followed by reflux for 3 hours. After distillation, 50.3 g of 2,2,2-trifluoroethyl trifluoromethanesulfonate was obtained in a yield of 73%.
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| | 2,2,2-Trifluoroethyl trifluoromethanesulfonate Preparation Products And Raw materials |
| Preparation Products | 2,2,2-Trifluoroethanol-->2,2,3,3,3-Pentafluoropropyl 2,2,2-trifluoroethyl carbonate-->4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole-->TFEC-->tert-butyl (1-(2,2,2-trifluoroethyl)piperidin-4-yl)carbaMate-->4-NITRO-1-(2,2,2-TRIFLUOROETHYL)-1H-PYRAZOLE-->ethyl 1-(2,2,2-trifluoroethyl)piperidine-4-carboxylate-->3-Methyl-5-(2,2,2-trifluoroethoxy)picolinonitrile-->2H-1-BENZAZEPIN-2-ONE 6-FLUORO-1,3,4,5-TETRAHYDRO-3-[4-[3-METHOXY-4-(4-METHYL-1H-IMIDAZOL-1-YL)PHENYL]-1H-1,2,3-TRIAZOL-1-YL]-1-(2,2,2-TRIFLUOROETHYL)--->(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)methanol-->5-BROMO-2-(2,2,2-TRIFLUORO-ETHOXY)-PYRIMIDINE |
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