- 2-Amino-5-nitrothiazole
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- $44.00 / 10kg
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2024-03-13
- CAS:121-66-4
- Min. Order: 500kg
- Purity: 99.9
- Supply Ability: 200tons
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| | 2-Amino-5-nitrothiazole Basic information | | Uses |
| | 2-Amino-5-nitrothiazole Chemical Properties |
| Melting point | 195-200 °C (dec.) (lit.) | | Boiling point | 345.1±15.0 °C(Predicted) | | density | 1.583 (estimate) | | refractive index | 1.6740 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | 95% ethanol: soluble1g/150g at 20°C | | form | Powder | | pka | 1.26±0.10(Predicted) | | color | Yellow | | Water Solubility | <0.1 g/100 mL at 20 ºC | | Sensitive | Light Sensitive | | Merck | 14,457 | | BRN | 126797 | | Stability: | Stable. Incompatible with strong acids, strong oxidizing agents, acid chlorides, acid anhydrides. | | InChIKey | MIHADVKEHAFNPG-UHFFFAOYSA-N | | CAS DataBase Reference | 121-66-4(CAS DataBase Reference) | | IARC | 3 (Vol. 31, Sup 7) 1987 | | EPA Substance Registry System | 2-Amino-5-nitrothiazole (121-66-4) |
| | 2-Amino-5-nitrothiazole Usage And Synthesis |
| Uses | Niltazoxanide USP Related Compound A 2-Amino-5-nitrothiazole. | | Chemical Properties | greenish yellow, to orange or brown powder | | Uses | 2-Amino-5-nitrothiazole was used as diazo component in the synthesis of monoazo disperse dyes. It was used as matrix during matrix-assisted laser desorption/ionization time-of-flight mass spectrometric study of oligonucleotide and protein. | | Definition | ChEBI: 2-Amino-5-nitrothiazole is a member of thiazoles and a C-nitro compound. | | Production Methods | Early production of 2-Amino-5-nitrothiazole was
based on nitration of 2-acetylaminothiazole
and careful hydrolysis. Direct nitration of
2-aminothiazole gives a cleaner product and is
best achieved by adding 2-aminothiazole nitrate [57530-25-3] to concentrated sulfuric acid
at 0 – 10 ℃. This process and the nitration of o-anisidine are the only large-scale
processes based on rearrangement of an amine
nitrate, and both are potentially hazardous due
to the possibility of runaway exothermic reactions. | | General Description | Greenish-yellow to orange-yellow fluffy powder or a brown chunky powder. Slightly bitter taste. Used as a veterinary medicine. | | Air & Water Reactions | Insoluble in water. | | Reactivity Profile | 2-Amino-5-nitrothiazole may be sensitive to light. Incompatible with nitric acid and sulfuric acid. Also incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides. A preparative hazard . | | Fire Hazard | Flash point data for 2-Amino-5-nitrothiazole are not available. 2-Amino-5-nitrothiazole is probably combustible. | | Safety Profile | Poison by intraperitoneal route. Experimental reproductive effects. Questionable carcinogen with experimental carcinogenic, tumorigenic, and neoplastigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SO,. Incompatible with HNO3 and H2SO4. An antiprotozoal agent. | | Potential Exposure |
2-Amino-5-nitrothiazole is a synthetic veterinary antiprotozoal agent used since 1950 to treat farm fowl and pigeons. It is also used as an intermediate in manufacturing a group of dyes known as disperse azo dyes. It is not known to occur as a natural product. People may be exposed to 2-amino-5-nitrothiazole through contact with birds treated with the drug, releases from poultry farms, and occupational exposures in the dye industry.
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| | 2-Amino-5-nitrothiazole Preparation Products And Raw materials |
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