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Nisoldipine

Nisoldipine Suppliers list
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Email: Abel@chembj.com
Products Intro: Product Name:Nisoldipine
CAS:63675-72-9
Purity:99% Package:2640/KG
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Nisoldipine
CAS:63675-72-9
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:63675-72-9
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Email: sales@mainchem.com
Products Intro: Product Name:Nisoldipine
CAS:63675-72-9
Company Name: Hebei Chisure Biotechnology Co., Ltd.
Tel: +8613292890173
Email: luna@speedgainpharma.com
Products Intro: Product Name:Nisoldipine
CAS:63675-72-9
Purity:99% Package:10G;100USD

Lastest Price from Nisoldipine manufacturers

  • Nisoldipine
  • US $100.00 / KG
  • 2019-07-06
  • CAS:63675-72-9
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 100KG
  • Nisoldipine
  • US $1.00 / kg
  • 2019-05-22
  • CAS:63675-72-9
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 500KG
  • Nisoldipine
  • US $10.00 / KG
  • 2019-04-30
  • CAS:63675-72-9
  • Min. Order: 10G
  • Purity: 99%
  • Supply Ability: 500kg/month
Nisoldipine Basic information
Product Name:Nisoldipine
Synonyms:1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-isobutyl ester;Nikameal;Ninobarucin;Nisomynard;3-Methyl 5-(2-Methylpropyl) (4R)-2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;Nisoldipine (Sular);3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(2-nitrophenyl)-, 3-Methyl 5-(2-Methylpropyl)ester;Nisoldipine-d4
CAS:63675-72-9
MF:C20H24N2O6
MW:388.41
EINECS:264-407-7
Product Categories:-;Calcium channel;Cardiovascular APIs;Active Pharmaceutical Ingredients;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:63675-72-9.mol
Nisoldipine Structure
Nisoldipine Chemical Properties
Melting point 147-148°C
storage temp. -20°C Freezer
solubility DMSO: >10mg/mL
form powder
color yellow
Merck 14,6565
InChIKeyVKQFCGNPDRICFG-UHFFFAOYSA-N
CAS DataBase Reference63675-72-9(CAS DataBase Reference)
NIST Chemistry ReferenceNisoldipine(63675-72-9)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22
Safety Statements 36
WGK Germany 3
RTECS US7975600
HS Code 2933399090
MSDS Information
Nisoldipine Usage And Synthesis
DescriptionNisoldipine D4  is another long-acting dihydropyridine calcium channel blocker effective in the treatment of hypertension and angina pectoris. It is reported to have little or no cardiodepressive activity and to be more effective than nifedipine in reducing blood pressure in hypertensives. Nisoldipine has also been shown to be effective in the management of congestive heart failure. Reduction in dosage is necessary in patients with hepatic, but not renal impairment.
Chemical PropertiesNisoldipine D4 is Light Tan Crystals
OriginatorBayer AG (Germany)
UsesDihydropyridine calcium channel blocker. Antihypertensive and antianginal
Usesurease inhibitor
UsesLabeled Nisoldipine, intended for use as an internal standard for the quantification of Nisoldipine by GC- or LC-mass spectrometry.
DefinitionChEBI: A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a methoxycarbonyl group at position 3, an o-nitrophenyl group at position 4, and an isobutoxycarbonyl group at position 5. The racemate, calcium channel blocker, is used in the treatment of hypertension and angina pectoris.
Brand nameSular (Sciele);Baymycard.
General DescriptionIn vitro studies show that the effects ofnisoldipine, 1,4-dihydro-2, 6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinecarboxylic acid methyl 2-methylpropyl ester(Sular), on contractile processes are selective, with greaterpotency on vascular smooth muscle than on cardiac muscle.
Nisoldipine is highly metabolized, with five majormetabolites identified. As with most of the dihydropyridines,the cytochrome P450 (CYP) 3A4 isozyme is mainlyresponsible for the metabolism of nisoldipine. The majorbiotransformation pathway appears to involve the hydroxylationof the isobutyl ester side chain. This particular metabolitehas approximately 10% of the activity of the parentcompound.
Nisoldipine Preparation Products And Raw materials
Raw materials2-Nitrobenzaldehyde-->Methyl 3-aminocrotonate-->Isobutyl acetoacetate
Tag:Nisoldipine(63675-72-9) Related Product Information
Nitrendipine Nicardipine Nimodipine 2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID Doxazosin 4-HYDROXYNISOLDIPINE NISOLDIPINE-D7 4-Acetoxynisoldipine Nisoldipine Dimethyl sulfate Dimethyl carbonate 2,5-PYRIDINEDICARBOXYLIC ACID p-Nitrobenzoic acid ETHANE 2,6-Dimethyl-7-octen-2-ol Quinolinic acid N,N-Dimethylformamide Dimethyl ether