ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Metabolism >Factor Xa inhibitor >Apixaban


Apixaban Suppliers list
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd
Tel: 010-60279497
Products Intro: Product Name:Apixaban
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Jinan Jianfeng Chemical Co., Ltd
Tel: 15562555968
Products Intro: Product Name:Apixaban
Purity:99% Package:5KG;1KG Remarks:Pharm api
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: Product Name:Apixaban
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Shanghai Yingrui Biopharma Co., Ltd.
Tel: +86-21-33585366
Products Intro: Product Name:Apixaban
Purity:99% Package:100g;500g;1kg;25kg...
Tel: +86 21 5161 9050/ 5187 7795
Products Intro: Product Name:Apixaban
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG

Lastest Price from Apixaban manufacturers

  • Apixaban
  • US $1.00-1.00 / KG
  • 2020-05-12
  • CAS:503612-47-3
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 50tons
  • Apixaban
  • US $0.00-0.00 / KG
  • 2020-05-12
  • CAS:503612-47-3
  • Min. Order: 5mg
  • Purity: 99%
  • Supply Ability: 2000tons

Related articles

  • Apixaban's related introduction
  • If you have atrial fibrillation (a condition in which the heart beats irregularly, increasing the chance of clots forming in t....
  • Aug 19,2019
Apixaban Basic information
Indications and Usage Mechanisms of Action Clinical Research Drug Interactions Warnings and Precautions
Product Name:Apixaban
Synonyms:Apixaban;Apixaban, BMS 562247-01;1H-Pyrazolo[3,4-c]pyridine-3-carboxamide, 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-;1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide;BMS562247;BMS 562247-01;1-(4-Methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid aMide;1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4, 5-dihydropyrazolo[3,4-c]pyridine-3-carboxaMide
Product Categories:Inhibitors;Inhibitor
Mol File:503612-47-3.mol
Apixaban Structure
Apixaban Chemical Properties
Boiling point 770.5±60.0 °C(Predicted)
density 1.42
Safety Information
MSDS Information
Apixaban Usage And Synthesis
Indications and UsageApixaban is a new form of oral anticoagulant drug developed by Bristol Myers Squibb and Pfizer. It is a new form of oral Xa factor inhibitor, and its commercial name is Eliquis. Apixaban is used to treat adult patients undergoing elective hip or knee replacement surgery to prevent venous thromboembolism (VTE)
Mechanisms of ActionApixaban is an oral selective activated Xa factor inhibitor and can prevent thrombin generation and thrombosis.
Clinical ResearchApixaban is the third new oral anticoagulant to go on sale, following dabigatran and rivaroxaban, and it has already been approved in Europe for preventing venous thromboembolism in patients undergoing elective hip or knee replacement surgery. Out of these three oral anticoagulants approved in Europe, compared to the current standard preventative treatment against venous thromboembolism, enoxaparin, rivaroxaban excelled in the record experiment, and apixaban excelled in the advance experiment. Rivaroxaban’s curative effects were slightly superior, but it caused more severe bleeding than apixaban. Researchers attributed these differences to medication time, as rivaroxaban was taken 6-8 hours after surgery in the record experiment, while apixaban was used 18 hours after surgery in the advance experiment. These drugs have better curative effect when used closer to time of surgery, but also have an increased bleeding risk. Clinical research showed that compared to a daily subdermal injection of 40mg enoxaparin, 2 oral 2.5mg dosages of apixaban had better preventative effects against venous thromboembolism following hip or knee replacement surgery and did not increase bleeding risk.
Drug Interactions1.A double inhibitor of strong CYP3A4 and P-gp increases apixaban’s blood levels: decrease Eliquis dosage to 2.5mg or avoid simultaneous usage.
2.A inductor of strong CYP3A4 and P-gp can decrease apixaban’s blood levels: avoid simultaneous usage.
Warnings and Precautions
  • Breastfeeding mothers should stop usage or stop breastfeeding.
  • Use during pregnancy is not advised.
  • Use while experiencing severe liver damage is not advised.
DescriptionEliquis (apixaban), a direct inhibitor of factor Xa (FXa), was approved by the European Commission on May 18, 2011 for prevention of venous thromboembolic events (VTE) in adult patients who have undergone elective hip or knee replacement surgery. The discovery of apixaban was the culmination of a succession of novel and innovative medicinal chemistry discoveries starting with the identification of nonpeptide leads, rational drug design using computer-aided and X-ray crystallographic information, and the building of drug-like properties through the systematic replacement of basic groups with neutral moieties. Apixaban arose from modifications to razaxaban by constraining a pyrazole amide to form a bicyclic pyrazolo-pyridinone scaffold. Optimization of the P1 group resulted in the identification of the nonbasic methoxy phenyl group, while a P4 piperidinone improved the balance of potency and pharmacokinetics with low Vdss. The synthesis of apixaban begins with the generation of a hydrazone of 4-methoxyaniline which is then used in a 3+2 cycloaddition with a dihydropiperidinone to form a bicyclic pyrazolo-pyridinone scaffold. The distal piperidinone group is installed using an Ullmann coupling reaction followed by aminolysis of an ethyl ester on the pyrazole ring to complete the synthesis of apixaban.
OriginatorBristol Myers Squibb Company (United States)
UsesApixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively.
DefinitionChEBI: A pyrazolopyridine that is 7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide substituted at position 1 by a 4-methoxyphenyl group and at position 6 by a 4-(2-oxopiperidin-1-yl)phenyl group. It is used for the prevention and treatment of thromboembolic diseases.
Brand nameEliquis
Apixaban Preparation Products And Raw materials
Tag:Apixaban(503612-47-3) Related Product Information
Voriconazole Apixaban IMpurity(BMS-591329-01) 5-chloro-N-(4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)pentanamide Apixaban IMpurity( 1,3-bis(4-bromophenyl)propan-2-one 3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Apixaban IMpurity 6 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester Rivaroxaban Bortezomib Edoxaban (tosylate Monohydrate) (+)-JQ1 MK-2206 2HCl Dabigatran Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide Apixaban IMpurity 5 (BMS-591329-01)