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SNS-032

SNS-032 Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: 571-85586718 +8613336195806
Email: sales@capotchem.com
Products Intro: Product Name:BMS-387032
CAS:345627-80-7
Purity:98% (Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 008657128800458; +8615858145714
Email: fandachem@gmail.com
Products Intro: Product Name:SNS032
CAS:345627-80-7
Package:as customers' requirement
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:SNS-032 (BMS-387032)
CAS:345627-80-7
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: Biochempartner
Tel: 0086-13720134139
Email: candy@biochempartner.com
Products Intro: Product Name:SNS-032
CAS:345627-80-7
Purity:98% HPLC LCMS Package:10G;20G
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-61398051 +8613650506873
Email: sales@chemdad.com
Products Intro: Product Name:N-5-(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl-1,3-thiazol-2-ylpiperidine-4-carboxamide
CAS:345627-80-7
Package:1kg,2kg,5kg,10kg,25kg

SNS-032 manufacturers

SNS-032 Basic information
Product Name:SNS-032
Synonyms:BMS-3870032 N-[5-[(5-tert-Butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide;N-[5-[(5-tert-Butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide SNS-032 (BMS-387032);N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamid;SNS-032, >=99%;N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide;BMS-387032;4-Piperidinecarboxamide, N-(5-(((5-(1,1-dimethylethyl)-2-oxazolyl)methyl)thio)-2-thiazolyl)-;N-(5-((5-Tert-Butyloxazol-2-yl)methylthio)thiazol-2-yl)piperidine-4-carboxamide
CAS:345627-80-7
MF:C17H24N4O2S2
MW:380.53
EINECS:
Product Categories:Inhibitors;Specific and potent inhibitor of cyclin-dependent kinases (CDK) 2, 7 and 9.;Aromatics;Heterocycles;Intermediates & Fine Chemicals. Sulfur & Selenium Compounds;Pharmaceuticals;Inhibitor of cyclin-dependent kinases (CDK) 2, 7 and 9.
Mol File:345627-80-7.mol
SNS-032 Structure
SNS-032 Chemical Properties
Melting point 171-173 °C
density 1.28±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka7.33±0.70(Predicted)
color White to Off-White
Safety Information
HS Code 29349990
MSDS Information
SNS-032 Usage And Synthesis
DescriptionCyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. SNS-032 is an ATP-competitive inhibitor of Cdk9, 2, and 7 with IC50 values of 4, 38, and 62 nM, respectively. It is selective for these kinases and displays no additional activity against a panel of 190 kinases (IC50s = >1,000 nM). SNS-032 can block the cell cycle, inhibit transcription, and induce apoptosis in multiple myeloma RPMI-8226 cells with an IC90 value of 0.3 μM. This compound has been shown to induce apoptosis by inhibiting the transcription of the anti-apoptotic proteins, Mcl-1 and XIAP.
Chemical PropertiesOff-White Solid
UsesSNS 032 is a selective inhibitor of Cyclin-dependent Kinase (CDK) 2,7, and 9.
DefinitionChEBI: N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide is a secondary carboxamide resulting from the formal condensation of the carboxy group of piperidine-4-carboxylic acid with the amino group of 5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-amine. It is an ATP-competitive inhibitor of CDK2, CDK7 and CDK9 kinases and exhibits anti-cancer properties. It has a role as an apoptosis inducer, an antineoplastic agent, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor and an angiogenesis inhibitor. It is a piperidinecarboxamide, a member of 1,3-oxazoles, a member of 1,3-thiazoles, an organic sulfide and a secondary carboxamide.
storageStore at -20°C
references[1]. tong w.g., chen r., plunkett w., et al. phase i and pharmacologic study of sns-032, a potent and selective cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma. journal of clinical oncology, 2010, 28(18):3015- 3022.
[2]. chipumuro e., marco e., christensen c.l., et al. cdk7 inhibition suppresses super-enhancer-linked oncogenic transcription in mycn-driven cancer. cell, 2014, 159:1-14.
[3]. meng h., jin y.m., liu h., et al. sns-032 inhibits mtorc1/mtorc2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against akt. journal of hematology & oncology, 2013, 6:18.
[4]. chen r., wierda w.g., chubb s., et al. mechanism of action of sns032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia. blood, 2009, 113(19):4637-4645.
SNS-032 Preparation Products And Raw materials
Tag:SNS-032(345627-80-7) Related Product Information
3,3-Dimethyl-1-butyne N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide hydrochloride N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea Y27632 (hydrochloride) Alisertib (MLN8237) PD 0332991 HCl (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Flavopiridol (Alvocidib) HCl Olaparib Hexahydroisonicotinamide 1-BOC-PIPERIDINE-4-CARBOXYLIC ACID [5-(5-TERT-BUTYL-OXAZOL-2-YLMETHYLSULFANYL)-THIAZOL-2-YL]-AMIDE SNS-032