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Pepstatin Suppliers list
Company Name: Alpha Biopharmaceuticals Co., Ltd
Tel: +86-411-39042497 +8613921981412
Products Intro: Product Name:Pepstain A
Purity:>97% Package:5g;25g;100g;250g;1kg;bulk Remarks:B0230
Tel: +undefined-21-51877795
Products Intro: Product Name:Pepstatin
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: career henan chemical co
Tel: +86-0371-86658258
Products Intro: Product Name:Pepstatin
Purity:99% Package:1KG;1USD
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Products Intro: Product Name:Pepstatin
Company Name: BOC Sciences
Tel: +16314854226
Products Intro: Product Name:Pepstatin A
Purity:>98% Package:500mg Remarks:BOC Sciences also provides custom synthesis services for Pepstatin A.

Pepstatin manufacturers

  • Pepstatin
  • Pepstatin pictures
  • $0.00 / 1KG
  • 2023-09-06
  • CAS:26305-03-3
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 500000kg
  • Pepstatin
  • Pepstatin pictures
  • $0.00 / 1KG
  • 2022-10-09
  • CAS:26305-03-3
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 1ton
  • Pepstatin
  • Pepstatin pictures
  • $0.00 / 1g
  • 2021-09-29
  • CAS:26305-03-3
  • Min. Order: 1g
  • Purity: 98.0%
  • Supply Ability: 1kg/month
Pepstatin Basic information
Product Name:Pepstatin
Synonyms:ahpatininc;pepsininhibitors735a;procidins735a;PEPSTATIN;X-VAL-VAL-STATYL-ALA-STATIN;AHMHA ISOVALERYL-L-VAL-L-VAL-AHMHA-L-ALA-STA;Pepstatin A, Ultra Pure;pepstatin|Pep A|PEP|peptistatin A|pepstatine A|Pepstatin A|pepstatine
Product Categories:Antibiotics;Inhibitor;peptides;Pepetides;ProteaseInhibitors
Mol File:26305-03-3.mol
Pepstatin Structure
Pepstatin Chemical Properties
Melting point 233 °C (dec.)(lit.)
alpha D27 -90.3° (c = 0.288 in methanol)
Boiling point 695.91°C (rough estimate)
density 1.1340 (rough estimate)
refractive index 1.7500 (estimate)
storage temp. 2-8°C
solubility 10% acetic acid in methanol: 1 mg/mL
form White solid
color Colorless needles
optical activityOptical rotation: -90.0 ± 5° (c = 0.5, MeOH, 20°C).
Water Solubility It is soluble in 10% (v/v) acetic acid in methanol (9:1 methanol:acetic acid) (1 mg/ml), ethanol (1-2 mg/ml with heat up to 60°C), DMSO (5 mg/ml), methanol (1 mg/ml), and acetic acid. Insoluble in benzene, chloroform, water, 1 M NaOH, and ether.
BRN 2201362
Stability:Stable. Incompatible with strong bases, strong acids.
CAS DataBase Reference26305-03-3(CAS DataBase Reference)
Safety Information
Safety Statements 22-24/25
WGK Germany 2
RTECS SC6155000
HS Code 29241990
ToxicityLD50 in mice, rats, rabbits, dogs (mg/kg): 1090, 875, 820, 450 i.p.; all >2000 orally (Umezawa, 1970)
Pepstatin Usage And Synthesis
DescriptionPepstatin A is a bacterial-derived chemotactic pentapeptide that irreversibly inhibits aspartic proteases, including pepsin, gastricsin, renin, cathepsin E, and cathepsin D. Pepstatin A has been reported to stimulate human neutrophil degranulation (EC50 = 0.75 μM) and super oxide production (EC50 = 1.5 μM). Pepstatin A has been widely used as a research tool in studies of protease mechanisms and biological functions and has been examined as a therapeutic agent for inflammatory conditions including gastric ulcer, edema, and hypertension.
Chemical Propertiessolid
UsesAntiviral;Aspartic proteases irreversible inhibitor
UsesPepstatin A are natural, statine-containing peptides that acts as inhibitor of aspartic protease enzymes.
UsesAs an aspartic proteases irreversible inhibitor, Pepstain A can be used in conjunction with E64-d and Leupeptin A to inhibit the degradation of autophagic cargo inside autophagosomes.
DefinitionChEBI: Pepstatin A is a pentapeptide isolated from Streptomyces testaceus. It is a potent inhibitor of aspartyl proteases. It has a role as a bacterial metabolite and an EC 3.4.23.* (aspartic endopeptidase) inhibitor. It is a pentapeptide and a secondary carboxamide. It is a conjugate acid of a pepstatin A(1-).
General DescriptionPepstatin A is a naturally occurring chemotactic peptide and inhibitor of aspartic proteases that was initially isolated from culture filtrates of various Actinomycetes species, with the initial name simply of “pepstatin”. This name was later modified to “pepstatin A” to distinguish the original pepstatin from later derivatives. Pepstatin A notably contains the unusual amino acid 4-amino-hydroxy-6-methylheptanoic acid (AHMHA), which is known also as statine. The amino acid sequence of pepstatin A is N-Isovaleryl-L-Valyl-L-Valyl-AHMHA-L-Alanyl-AHMHA.
Biochem/physiol ActionsPrimary Targetaspartic proteases
Safety ProfileModerately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.
Enzyme inhibitorThis naturally occurring statine-containing peptidomimetic (FWfree-acid = 685.90 g/mol; CAS 26305-03-3), also called pepstatin A and isovalerylpepstatin and named systematically as N-(isovaleryl)-L-valyl-L-valyl-statylL-alanyl-statine (where the statyl residue is a (3S,4S)-4-amino-3-hydroxy-6- methylheptanoyl residue and the C-terminal statine is the corresponding acid), is a presumptive transition-state analogue for prototypical aspartate proteinase pepsin (Ki = 46 pM). Pepstatin will also inhibit other carboxy proteinases. The inhibitory effectiveness of statine-containing peptides has been widely exploited by incorporating the statine residue into peptides that otherwise match sequence preferences of the target enzyme’s sub-sites. Because pepstatin has a low solubility in water, it is often dissolved indimethyl sulfoxide, methanol, or ethanol. Note that many derivatives of pepstatin are available, each displaying a different spectrum of inhibitory effects. Pepstatin B and C are the N-(n-caproyl)- and N-(iso-caproyl)- derivatives, respectively. Note: Above a critical concentration of 0.1 mM in low ionic-strength and neutral buffers, pepstatin often polymerizes into filaments that be several micrometers in length and have characteristic diameters ranging between 6 and 12 nm
References1) Merck Index 14:7147 2) Marciniszyn?et al.?(1976)?Mode of inhibition of acid proteases by pepstatin; J. Biol. Chem.,?251?7088 3) Oda (2012)?New families of carboxy peptidases: serine-carboxyl peptidases and glutamic peptidases; J. Biochem.,?151?13 4) Yoshida?et al. (2006)?Pepstatin A, an aspartic proteinase inhibitor, suppresses RANKL-induced osteoclast differentiation; J. Biochem.,?139?583
Pepstatin Preparation Products And Raw materials
Raw materialsFMOC-Ala-OH-->FMOC-STA-OH-->FMOC-L-Valine-->Isovaleric acid
Tag:Pepstatin(26305-03-3) Related Product Information
Methyl Pepstatin AC 1 VIAL PROTEASE-INHIBITOR-MIX HP 1-[N-(1-Oxooctyl)-L-valyl]pepstatin A,Pepstatin G Butanamide, N-(4-amino-4-oxobutyl)- PEPSTATIN A-AGAROSE PEPSTATIN PROTEOMICS 1-[N-(1-Oxoheptyl)-L-valyl]pepstatin A,Pepstatin D SIGMACHROM AF-PEPSTATIN 5CM X 8MM 20UM (S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID Pepstatin A (1.24825) Saccharated Pepsin AC-VAL-NH2 pepstatin ketone analog CHLOROPHOSPHONAZO III 1-[N-(7-Methyl-1-oxooctyl)-L-valyl]pepstatin A,Pepstatin I 1-[N-(6-Methyl-1-oxoheptyl)-L-valyl]pepstatin A,Pepstatin H DL-4-Amino-3-hydroxybutyric acid