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Pepstatin

Pepstatin Suppliers list
Company Name: Alpha Biopharmaceuticals Co., Ltd
Tel: 0086-411-39042497
Email: sales@alphabiopharm.com
Products Intro: Product Name:Pepstain A
CAS:26305-03-3
Purity:>97% Package:5g;25g;100g;250g;1kg;bulk Remarks:B0230
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +86 21 5161 9050/ 5187 7795
Email: ivan@atkchemical.com
Products Intro: Product Name:Pepstatin
CAS:26305-03-3
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Pepstatin
CAS:26305-03-3
Purity:99% Package:1KG;1USD
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Email: linda@hubeijusheng.com
Products Intro: Product Name:Pepstatin
CAS:26305-03-3
Company Name: BOC Sciences
Tel: 1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:Pepstatin A
CAS:26305-03-3
Purity:>98%

Lastest Price from Pepstatin manufacturers

  • Pepstatin
  • US $0.00-0.00 / g
  • 2021-09-29
  • CAS:26305-03-3
  • Min. Order: 1g
  • Purity: 98.0%
  • Supply Ability: 1kg/month
  • Pepstatin
  • US $15.00-10.00 / KG
  • 2021-07-13
  • CAS:26305-03-3
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Pepstatin
  • US $15.00-10.00 / KG
  • 2021-07-10
  • CAS:26305-03-3
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
Pepstatin Basic information
Product Name:Pepstatin
Synonyms:ahpatininc;pepsininhibitors735a;procidins735a;PEPSTATIN;PEPSTATIN A;X-VAL-VAL-STATYL-ALA-STATIN;(3S,4S)-4-AMINO-3-HYDROXY-6-METHYL-HEPTANOIC ACID;AHMHA ISOVALERYL-L-VAL-L-VAL-AHMHA-L-ALA-STA
CAS:26305-03-3
MF:C34H63N5O9
MW:685.89
EINECS:247-600-0
Product Categories:Antibiotics;Inhibitor;Pepetides;ProteaseInhibitors;peptides
Mol File:26305-03-3.mol
Pepstatin Structure
Pepstatin Chemical Properties
Melting point 233 °C (dec.)(lit.)
alpha D27 -90.3° (c = 0.288 in methanol)
Boiling point 695.91°C (rough estimate)
density 1.1340 (rough estimate)
refractive index 1.7500 (estimate)
storage temp. 2-8°C
solubility 10% acetic acid in methanol: 1 mg/mL
form White solid
pka4.17±0.10(Predicted)
color Colorless needles
optical activityOptical rotation: -90.0 ± 5° (c = 0.5, MeOH, 20°C).
Water Solubility It is soluble in 10% (v/v) acetic acid in methanol (9:1 methanol:acetic acid) (1 mg/ml), ethanol (1-2 mg/ml with heat up to 60°C), DMSO (5 mg/ml), methanol (1 mg/ml), and acetic acid. Insoluble in benzene, chloroform, water, 1 M NaOH, and ether.
BRN 2201362
Stability:Stable. Incompatible with strong bases, strong acids.
InChIKeyJKGWASGTXVCDML-LXTPJMTPSA-N
CAS DataBase Reference26305-03-3(CAS DataBase Reference)
Safety Information
Safety Statements 22-24/25
WGK Germany 2
RTECS SC6155000
10
HS Code 29241990
ToxicityLD50 in mice, rats, rabbits, dogs (mg/kg): 1090, 875, 820, 450 i.p.; all >2000 orally (Umezawa, 1970)
Pepstatin Usage And Synthesis
Chemical Propertiessolid
UsesAntiviral;Aspartic proteases irreversible inhibitor
UsesAs an aspartic proteases irreversible inhibitor, Pepstain A can be used in conjunction with E64-d and Leupeptin A to inhibit the degradation of autophagic cargo inside autophagosomes.
Safety ProfileModerately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.
Enzyme inhibitorThis naturally occurring statine-containing peptidomimetic (FWfree-acid = 685.90 g/mol; CAS 26305-03-3), also called pepstatin A and isovalerylpepstatin and named systematically as N-(isovaleryl)-L-valyl-L-valyl-statylL-alanyl-statine (where the statyl residue is a (3S,4S)-4-amino-3-hydroxy-6- methylheptanoyl residue and the C-terminal statine is the corresponding acid), is a presumptive transition-state analogue for prototypical aspartate proteinase pepsin (Ki = 46 pM). Pepstatin will also inhibit other carboxy proteinases. The inhibitory effectiveness of statine-containing peptides has been widely exploited by incorporating the statine residue into peptides that otherwise match sequence preferences of the target enzyme’s sub-sites. Because pepstatin has a low solubility in water, it is often dissolved indimethyl sulfoxide, methanol, or ethanol. Note that many derivatives of pepstatin are available, each displaying a different spectrum of inhibitory effects. Pepstatin B and C are the N-(n-caproyl)- and N-(iso-caproyl)- derivatives, respectively. Note: Above a critical concentration of 0.1 mM in low ionic-strength and neutral buffers, pepstatin often polymerizes into filaments that be several micrometers in length and have characteristic diameters ranging between 6 and 12 nm
Pepstatin Preparation Products And Raw materials
Raw materialsFMOC-Ala-OH-->FMOC-STA-OH-->FMOC-L-Valine-->Isovaleric acid
Tag:Pepstatin(26305-03-3) Related Product Information
1-[N-(6-Methyl-1-oxoheptyl)-L-valyl]pepstatin A,Pepstatin H 1-[N-(1-Oxooctyl)-L-valyl]pepstatin A,Pepstatin G 1-[N-(1-Oxoheptyl)-L-valyl]pepstatin A,Pepstatin D pepstatin ketone analog Pepstatin AC Pepstatin A (1.24825) SIGMACHROM AF-PEPSTATIN 5CM X 8MM 20UM PEPSTATIN A-AGAROSE PEPSTATIN PROTEOMICS Methyl AC-VAL-NH2 STATINE (S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID AC-VAL-NHME DL-4-Amino-3-hydroxybutyric acid Butanamide, N-(4-amino-4-oxobutyl)- 1 VIAL PROTEASE-INHIBITOR-MIX HP Saccharated Pepsin