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| | 6-Acetamidohexanoic acid Basic information |
| | 6-Acetamidohexanoic acid Chemical Properties |
| Melting point | 102-104 °C(lit.) | | Boiling point | 303.86°C (rough estimate) | | density | 1.1599 (rough estimate) | | refractive index | 1.4590 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Sparingly), Methanol (Slightly) | | pka | 4.75±0.10(Predicted) | | form | Solid | | color | White to Off-White | | Merck | 14,45 | | LogP | -0.500 (est) | | CAS DataBase Reference | 57-08-9(CAS DataBase Reference) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | HS Code | 29241900 |
| | 6-Acetamidohexanoic acid Usage And Synthesis |
| Chemical Properties | WHITE POWDER | | Originator | Acexamic acid ,Flamma | | Uses | wound healing agent | | Uses | 6-Acetamidohexanoic acid is used after oral administration of an antiulcer agent, zinc acexamate (ZAC) for treatment of gastric ulcer or small bowel inflammation. | | Definition | ChEBI: Acexamic acid is a medium-chain fatty acid. | | Manufacturing Process | 400 L of demineralized water, 5.0 kg of calcium hydroxide, and 155.0 kg
(1000 moles) of acetyl-caprolactame are introduced under stirring and at a
temperature of about 25°C into a 1000 L stainless double walled reactor.
The temperature is raised to 30°C. 75.0 kg of calcium hydroxide are
introduced stepwise in the form of successive amounts of 2.0 kg each in the
medium, under stirring and at a temperature adjusted and maintained 25°-
30°C through external cooling, in a manner such that the time required to
introduce into the reactor the whole amount of calcium hydroxide
approximates 1.5 h. When the stirring is stopped, the pH is about 7.5-7.8.
The obtained mixture is stirred continuously at a temperature of 30°C during
14 h. At the end of this operation the pH is again adjusted at a value 7.5-7.8.
The hydrolysate is filtered on a 60 x 60 pressfilter comprising 6 compartments
and equipped with fabrics of the polyester known under the designation
TERGAL which have been previously coated with a suspension of a cellulose
commercialized under the trademark SOLKA FLOX BW20. The duration of
filtration is of 1.5 h. 580 L of the filtrate are recovered and subjected to a
concentration under reduced pressure in an evaporator the volume of which is
of 750 L, at a distillation temperature ranging from 45°-50°C under a reduced
pressure of 10-15 Torr.
The operation is ran until concentration of the solution to 280 L, the
concentrated solution being then left standing. The crystallisation is already
considerable 2 h after the end of the operation of concentration.
Crystallisation is ended after 16-24 h.
The crystals are centrifuged at a speed of 700 revolutions/minute. The
centrifuged crystals of calcium acexamate are washed twice on the centrifuge
with 20 l of acetone. 107.0 kg of crystals are obtained, which are dried under
vacuum at 40°C. The 96.0 kg of dry calcium acexamate obtained are ground
and sifted.
Acexamic acid may be produced by treatment of the calcium acexamate with
HCl. | | Therapeutic Function | Antifibrinolytic |
| | 6-Acetamidohexanoic acid Preparation Products And Raw materials |
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