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BOC Sciences
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| Products Intro: |
Product Name:CAY10734
CAS:635701-59-6
Purity:>=98% Remarks:Reach out to us for more information about custom solutions.
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Merck SIP Agonist manufacturers
- CAY10734
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- $595.00 / 10mg
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2024-11-19
- CAS:635701-59-6
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Merck SIP Agonist Basic information |
| Product Name: | Merck SIP Agonist | | Synonyms: | Merck SIP Agonist;butylphenyl)-1,2,4-oxadiaz1-(4-(5-(4-isool-3-yl)benzyl)azetidine-3-carboxylic acid;1-(4-(5-(4-Isobutylphenyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid;3-Azetidinecarboxylic acid, 1-[[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]-;1-[4-[5-[4-(2-Methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]benzyl]azetidine-3-carboxylic acid;CS-126;CAY10734;SHQNRSGKLNMHOS-UHFFFAOYSA-N | | CAS: | 635701-59-6 | | MF: | C23H25N3O3 | | MW: | 391.46 | | EINECS: | | | Product Categories: | | | Mol File: | 635701-59-6.mol |  |
| | Merck SIP Agonist Chemical Properties |
| Boiling point | 565.9±60.0 °C(Predicted) | | density | 1.228±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 5 mg/ml; DMF:PBS (pH 7.2) (1:10): 0.1 mg/ml; Ethanol: Partially soluble | | form | A crystalline solid | | pka | 2.66±0.20(Predicted) |
| | Merck SIP Agonist Usage And Synthesis |
| Description | CAY10734 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1; IC50 = 0.6 nM). It selectively binds S1P1 over S1P2, S1P3, and S1P4 receptors (IC50s = >10,000, 12,000, and 70 nM, respectively) but does also bind S1P5 receptors (IC50 = 1 nM) in radioligand binding assays. CAY10734 reduces the number of peripheral blood lymphocytes in mice, rats, and dogs, with the maximal response achieved when administered at doses of 10, 0.5, and 0.5 mg/kg, respectively. It increases graft survival in a rat skin allograft model when administered at a dose of 5 mg/kg per day in combination with cyclosporin A (CsA; ). | | References | [1] ZHEN LI. Discovery of Potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 (S1P1) Receptor Agonists with Exceptional Selectivity against S1P2 and S1P3[J]. Journal of Medicinal Chemistry, 2005, 48 20: 6169-6173. DOI: 10.1021/jm0503244 |
| | Merck SIP Agonist Preparation Products And Raw materials |
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