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| | 2-(Trimethylsilyl)thiazole Basic information |
| | 2-(Trimethylsilyl)thiazole Chemical Properties |
| Boiling point | 56-57 °C10 mm Hg(lit.) | | density | 0.985 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.497(lit.) | | Fp | 135 °F | | storage temp. | Inert atmosphere,2-8°C | | solubility | THF: very soluble(lit.) | | form | Liquid | | pka | 2.91±0.10(Predicted) | | color | Clear colorless to slightly yellow | | Specific Gravity | 0.99 | | Water Solubility | IMMISCIBLE | | Hydrolytic Sensitivity | 7: reacts slowly with moisture/water | | BRN | 3538017 | | CAS DataBase Reference | 79265-30-8(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 23-24/25-26 | | RIDADR | 1993 | | WGK Germany | 3 | | F | 10-21 | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29341000 |
| | 2-(Trimethylsilyl)thiazole Usage And Synthesis |
| Chemical Properties | Colorless to light yellow liqui | | Physical properties | bp 51–53 °C/10 mmHg; d 0.992 g mL?1; nD 1.4980. | | Uses | 2-(Trimethylsilyl)thiazole is used as formyl anion equivalent; effective one-carbon homologating reagent of alkoxy aldehydes, amino aldehydes, and
dialdoses.It takes part in the reactions of Homologation of Aldehydes, Metalation and Reactivity with Electrophiles, Cross-coupling Reactions, etc. | | Preparation | Although 2-(trimethylsilyl)thiazole (1) is
commercially available, it can be easily prepared on a multigram scale from 2-bromothiazole, n-butyllithium, and chlorotrimethylsilane as shown in eq 1. 
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| | 2-(Trimethylsilyl)thiazole Preparation Products And Raw materials |
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