| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:PI 828;2-(4-Morpholinyl)-8-(4-aMinopheny)l-4H-1-benzopyran-4-one
CAS:942289-87-4
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
EMMX Biotechnology LLC
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| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:PI 828
CAS:942289-87-4
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| Product Name: | PI 828 | | Synonyms: | PI 828;2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one;8-(4-Aminophenyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one;8-(4-aminophenyl)-2-morpholin-4-ylchromen-4-one;LY 294002, 4-NH - CAS 942289-87-4 - Calbiochem;LY 294002, 4′-NH2;PI 828,PI828;4H-1-Benzopyran-4-one, 8-(4-aminophenyl)-2-(4-morpholinyl)- | | CAS: | 942289-87-4 | | MF: | C19H18N2O3 | | MW: | 322.36 | | EINECS: | | | Product Categories: | | | Mol File: | 942289-87-4.mol |  |
| | PI 828 Chemical Properties |
| Boiling point | 534.2±50.0 °C(Predicted) | | density | 1.316±0.06 g/cm3(Predicted) | | storage temp. | Store at +4°C | | solubility | DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: slightly soluble | | pka | 4.14±0.10(Predicted) | | form | Off-white solid |
| | PI 828 Usage And Synthesis |
| Definition | ChEBI: 8-(4-aminophenyl)-2-(4-morpholinyl)-1-benzopyran-4-one is a member of chromones. | | General Description | A cell-permeable LY 294002 (Cat. Nos. 440202 & 440204) 4′-amino derivative with enhanced potency against p110α/β/δ/γ (IC50 in nM/-fold increase in potency = 183/2.7-, 98/5.7-, 1227/.5-, and 1967/1.9-, respectively). The molecule has been immobilized on epoxy-containing solid surface via the 4′-amine for binding studies and shown to interact with non-PI3K cellular proteins, such as mTOR, ALDH1, Brd4, GSK3β, and CKIIα. | | Biological Activity | PI 3-Kinase inhibitor (IC 50 values are 0.098, 0.183, 0.227 and 1.967 μ M for p110 β , p110 α , p110 δ and p110 γ respectively) that displays higher potency than LY 294002 (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride). Can be immobilized onto a solid phase. | | storage | Store at +4°C |
| | PI 828 Preparation Products And Raw materials |
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