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| | ATN-224 Basic information |
| Product Name: | ATN-224 | | Synonyms: | ATN-224;Bis(choline)tetrathioMolybdate;ATN-224
(Choline tetrathiomolybdate;WTX-101);Choline tetrathiomolybdate;CHOLINE TETRATHIOMOLYBDATE;WTX-101;WTX 101;WTX101;bis(sulfanylidene)molybdenum,2-hydroxyethyl(trimethyl)azanium,sulfanide;2-Hydroxy-N,N,N-trimethylethanaminium tetrathiomolybdate | | CAS: | 649749-10-0 | | MF: | C5H14MoNOS4- | | MW: | 328.36 | | EINECS: | | | Product Categories: | | | Mol File: | 649749-10-0.mol |  |
| | ATN-224 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO:20.0(Max Conc. mg/mL);46.24(Max Conc. mM)
DMSO:PBS (pH 7.2):0.5(Max Conc. mg/mL);1.16(Max Conc. mM) | | form | A crystalline solid |
| | ATN-224 Usage And Synthesis |
| Description | ATN-224 is a choline salt of tetrathiomolybdate and an inhibitor of superoxide dismutase 1 (SOD1; IC50s = 2.91 and 3.51 μM in human and mouse blood cells, respectively, in vitro). ATN-224 reduces the viability of cultured oxidative stress-resistant WEHI7.2 murine thymic lymphoma cells (EC50s = 5-6 nM) and human diffuse large B cell lymphoma cell lines (EC50s = 9.73-105.61 nM) independently of Bcl-2 and Bcl-xL. In vivo, ATN-224 (0.7 mg/kg) chelates copper to stabilize an antitumor viral vector, enhancing its efficacy against lung metastases in mice. It also inhibits angiogenesis in a mouse model (IC50s = 1.50-3 mg/kg via gavage). |
| | ATN-224 Preparation Products And Raw materials |
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