SET8 Methyltransferase Inhibitor Screening Assay Kit

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Company Name: Cayman Chemical Company  
Tel: 800-364-9897
Email: sales@caymanchem.com
Company Name: Cayman Chemical Company  
Tel: (800) 364-9897
Email: cayman@caymanchem.com
SET8 Methyltransferase Inhibitor Screening Assay Kit Basic information
Product Name:SET8 Methyltransferase Inhibitor Screening Assay Kit
Synonyms:SET8 Methyltransferase Inhibitor Screening Assay Kit
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MW:0
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SET8 Methyltransferase Inhibitor Screening Assay Kit Structure
SET8 Methyltransferase Inhibitor Screening Assay Kit Chemical Properties
Safety Information
MSDS Information
SET8 Methyltransferase Inhibitor Screening Assay Kit Usage And Synthesis
DescriptionSET Domain-containing Protein 8 (SET8) is a methyltransferase that selectively mono-methylates histone H4 at lysine residue 20 (H4K20), an event proven to have an important role in chromatin structure and transcriptional activation. Cayman’s SET8 Methyltransferase Inhibitor Screening Assay provides a convenient method for screening human SET8 inhibitors. The transfer of the methyl group from SAM by SET8 (provided in the kit) to the acceptor peptide (H4K20) generates S-adenosylhomocysteine, which is rapidly converted to urate and hydrogen peroxide (H2O2) using an enzyme mixture provided in the kit. The H2O2 formed is quantified using 10-acetyl-3,7-dihydroxyphenoxazine (ADHP) to produce the highly fluorescent compound resorufin (excitation 530-540 nm; emission 585-595 nm).Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.WARNING This product is not for human or veterinary use.
SET8 Methyltransferase Inhibitor Screening Assay Kit Preparation Products And Raw materials
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