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| | (3-Chloropyrazin-2-yl)MethanaMine hydrochloride Basic information |
| Product Name: | (3-Chloropyrazin-2-yl)MethanaMine hydrochloride | | Synonyms: | 3-Chloro-2-pyrazinemethanamine hydrochloride;2-Pyrazinemethanamine, 3-chloro-, hydrochloride (1:1);QC-6916;3-Chloropyrazine-2-yl-methylamine hydrochloride;(3-chloropyrazin-2-yl)methanamine,hydrochloride (1:1);(3-Chloropyrazin-2-yl)methanamine hydrochloride 96%;3-chloro-2-pyrazine methane amine hydrochloride;(3-chloropyrazin-2-yl)methanamine hydrochloride | | CAS: | 939412-86-9 | | MF: | C5H7Cl2N3 | | MW: | 180.03 | | EINECS: | | | Product Categories: | | | Mol File: | 939412-86-9.mol |  |
| | (3-Chloropyrazin-2-yl)MethanaMine hydrochloride Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | solid | | color | Yellow | | InChI | InChI=1S/C5H6ClN3.ClH/c6-5-4(3-7)8-1-2-9-5;/h1-2H,3,7H2;1H | | InChIKey | YYVVOYJKQZWKFS-UHFFFAOYSA-N | | SMILES | C(C1=NC=CN=C1Cl)N.Cl |
| | (3-Chloropyrazin-2-yl)MethanaMine hydrochloride Usage And Synthesis |
| Synthesis | General procedure for the synthesis of (3-chloropyrazin-2-yl)methanamine hydrochloride from 2-chloro-3-cyanopyrazine: To a solution of 3-chloropyrazine-2-carbonitrile (Compound 101) (6.00 g, 43.0 mmol, 1.0 eq.) in acetic acid (50 mL) was added nickel Ruanne (4.00 g). The reaction was carried out for 1.5 days at room temperature under the protection of a hydrogen balloon. After completion of the reaction, the reaction mixture was filtered and the filtrate was collected and dried. The residue was treated by rotary evaporation with toluene (40 mL), 1N HCl (15 mL), and toluene (40 mL) in that order. The resulting residue was dissolved in tetrahydrofuran (30 mL) and filtered to remove insoluble material. The filtrate was rotary evaporated to dryness to give (3-chloropyrazin-2-yl)methylamine hydrochloride (8.75 g, yield: 100%). The product was a black solid. | | References | [1] Patent: CN106588937, 2017, A. Location in patent: Paragraph 0152; 0158; 0159
[2] Patent: WO2013/10869, 2013, A1. Location in patent: Page/Page column 25
[3] Patent: WO2013/10868, 2013, A1. Location in patent: Page/Page column 29-30
[4] Patent: EP2548877, 2013, A1. Location in patent: Paragraph 0143
[5] Patent: WO2016/24227, 2016, A1. Location in patent: Paragraph 00207 |
| | (3-Chloropyrazin-2-yl)MethanaMine hydrochloride Preparation Products And Raw materials |
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