二甲基姜黄素
中文名称 | 二甲基姜黄素 |
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中文同义词 | 二甲基姜黄素;四甲基姜黄素;ASC-J9 生产厂家;二甲基姜黄素, ≥95%;二甲基姜黄素 ASC-J9;(1E,4Z,6E)-1,7-双(3,4-二甲氧基苯基)-5-羟基庚-1,4,6-三烯-3-酮;4′,4″-O,O-二甲基姜黄素-D6;ASC-J9,二甲基姜黄素 |
英文名称 | ASC-J9 |
英文同义词 | 1,4,6-Heptatrien-3-one, 1,7-bis(3,4-diMethoxyphenyl)-5-hydroxy-,(1E,4Z,6E)-;(1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one;Dimethylcurcumin;GO-Y 025;(1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one (ASC-J9);Dimethylcurcumin, ≥95%;Dimethylcurcumin【(1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one】;Indiscriminate |
CAS号 | 52328-98-0 |
分子式 | C23H24O6 |
分子量 | 396.43 |
EINECS号 | 2017-001-1 |
相关类别 | 标准品;对照品;中药对照品;植物提取物;分析试剂标准品;对照品-中药对照品;标准品 -中药标准品 |
Mol文件 | 52328-98-0.mol |
结构式 |
二甲基姜黄素 性质
熔点 | 129-130℃ |
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沸点 | 588.6±50.0 °C(Predicted) |
密度 | 1.191 |
储存条件 | Store at -20°C |
溶解度 | 不溶于乙醇;不溶于水; ≥16.65 mg/mL,溶于 DMSO |
形态 | 固体 |
酸度系数(pKa) | 8.34±0.60(Predicted) |
Target | Value |
AR
() |
Dimethylcurcumin (ASC-J9) is able to degrade fAR and AR3 in a dose-dependent manner in various human PCa cells. Dimethylcurcumin (ASC-J9) can also effectively suppress AR-targeted genes in CWR22Rv1-fARKD cells. Dimethylcurcumin (ASC-J9) (5 or 10 µM) significantly suppresses the DHT-induced cell growth in all three PCa cell lines. Dimethylcurcumin (ASC-J9) suppresses AR-targeted genes and cell growth by degradation of fAR and ectopic AR3 in C81 and C4-2 cells. Dimethylcurcumin (ASC-J9) selectively promotes AR degradation by disrupting the interaction between AR and AR coregulators. ASC-J9 reduces the AR aggregated AR-112Q in cells. Dimethylcurcumin (ASC-J9) suppresses the aggregation of AR-112Q in SBMA PC12/AR-112Q cells.
Dimethylcurcumin (ASC-J9) (75 mg/kg, i.p.) degrades both fAR and AR3 in the xenografted tumors in vivo, and SC-J9-treated tumors has significantly decreased Ki67-positive cells. Dimethylcurcumin (ASC-J9) (50 mg/kg every 48 h, i.p.) substantially ameliorates the SBMA symptoms in AR-97Q mice, and ameliorates neuromuscular pathological findings. The Dimethylcurcumin (ASC-J9)-treated SBMA mice have relatively normal serum testosterone concentrations. ASC-J9-treated mice show significantly smaller prostate tumor sizes when compared with those receiving classic ADT/castration with little serum androgen.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/01/25 | HY-15194 | 二甲基姜黄素 Dimethylcurcumin | 52328-98-0 | 5mg | 540元 |
2024/01/25 | HY-15194 | 二甲基姜黄素 Dimethylcurcumin | 52328-98-0 | 10mM * 1mLin DMSO | 594元 |