| Company Name: |
Shanghai Tauto Biotech Co., Ltd.
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| Tel: |
021-51320588 |
| Email: |
tauto@tautobiotech.com |
| Products Intro: |
Product Name:IliMaquinone
CAS:71678-03-0
Purity:NLT 95% HPLC Package:10Mg;20Mg;50Mg;100Mg to graMs.Not More than tens of graMs. Remarks:AG-CN2-0038-C100
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| Company Name: |
Hotechem Shanghai Co., Ltd.,
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| Tel: |
021-34621078 13120882795 |
| Email: |
465106944@qq.com |
| Products Intro: |
Product Name:ILIMAQUINONE
CAS:71678-03-0
Purity:98% Package:25g;100g;250g;500g;1kg;5kg
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Ilimaquinone
CAS:71678-03-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | ILIMAQUINONE Basic information |
| Product Name: | ILIMAQUINONE | | Synonyms: | 3-[(DECAHYDRO-1B,2B,4AB-TRIMETHYL-5-METHYLENE-1-NAPHTHYL)METHYL]-2-HYDROXY-5-METHOXYBENZOQUINONE;3-[(DECAHYDRO-1BETA,2BETA,4A-BETA-TRIMETHYL-5-METHYLENE-1-NAPHTHYL)-METHYL]-2-HYDROXY-5-METHOXYBENZOQUINONE;3-[(DECAHYDRO-1BETA,2BETA,4A-BETA-TRIMETHYL-5-METHYLENE-1-NAPTHYL)METHYL]-2-HYDROXY-5-METHOXYBENZOQUINONE;3-[(DECAHYDRO-1BETA,2BETA,4ALPHA-BETA-TRIMETHYL-5-METHYLENE-1-NAPHTHYL)METHYL]-2-HYDROXY-5-METHOXYBENZOQUINONE;IQ;ILIMAQUINONE;3-[(decahydro-1β,2β,4aβ-trimethyl-5-methylene-1-naphthyl)methyl]-2-hydroxy-5-methoxybenzoquinone;illimaquinone | | CAS: | 71678-03-0 | | MF: | C22H30O4 | | MW: | 358.47 | | EINECS: | | | Product Categories: | | | Mol File: | 71678-03-0.mol |  |
| | ILIMAQUINONE Chemical Properties |
| Melting point | 108-110℃ (pentane ) | | alpha | D23 -23.2° (c = 1.12 in CHCl3) | | Boiling point | 478.4±45.0 °C(Predicted) | | density | 1.14±0.1 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | DMSO: Soluble; Ethanol: Soluble; Hexane: Soluble; Methanol: Soluble | | pka | 2.92±0.50(Predicted) | | form | Red solid |
| | ILIMAQUINONE Usage And Synthesis |
| Description | Ilimaquinone is a natural sesquiterpene quinone that has antimicrobial, anti-HIV, anti-mitotic, and anti-inflammatory properties. In mammalian cells, 25 μM ilimaquinone reversibly induces vesiculation of Golgi membranes, blocking the secretory pathway. It inhibits the conversion of S-adenosylhomocysteine (SAH) to homocysteine by SAH hydrolase (IC50 = 40 μM). Ilimaquinone also inhibits DNA polymerase β and dual specificity phosphatase Cdc25B (IC50 = 45.2 and 92 μM, respectively) and, at 10 μM, activates gene expression through hypoxia-inducible factor-1. | | Uses | Biological probe for intracellular communications and vesicle-mediated transport. | | Uses | Ilimaquinone is an ADP-ribosylation factor (ARF) and β-COP to the Golgi membrane inhibitor. | | Definition | ChEBI: A natural product found in Dactylospongia elegans. | | General Description | A cell-permeable marine sponge metabolite with anti-microbial, anti-HIV, anti-inflammatory, and anti-mitotic properties. Induces a complete and reversible breakdown of Golgi membranes into smaller vesicular structures and causes depolymerization of microtubules. Inhibits cellular methylations through its interaction with S-adenosylhomocysteinase. Blocks the cytotoxicity of ricin and diphtheria toxin. Acts as an inhibitor of the RNase H activity of HIV-1. | | Biochem/physiol Actions | Primary TargetInduces a complete and reversible breakdown of Golgi membranes into smaller vesicular structures and causes depolymerization of microtubules. |
| | ILIMAQUINONE Preparation Products And Raw materials |
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