CS-2357
| 中文名称 | CS-2357 |
|---|---|
| 中文同义词 | 化合物PF4840154;N-苄基-4-(异丁胺基)-2-(4-((四氢-2H-吡喃-3-基)甲基)哌嗪-1-基)嘧啶-5-甲酰胺 |
| 英文名称 | 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- |
| 英文同义词 | 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-;CS-2357;4-[(2-Methylpropyl)amino]-N-(phenylmethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)methyl]-1-piperazinyl]-5-pyrimidinecarboxamide;N-benzyl-4-(isobutylamino)-2-(4-((tetrahydro-2H-pyran-3-yl)methyl)piperazin-1-yl)pyrimidine-5-carboxamide;PF 4840154,PF-4840154,licking,nocifensive,Inhibitor,non-electrophilic,PF4840154,inhibit,Transient receptor potential channels,behavior,TRP Channel |
| CAS号 | 1332708-14-1 |
| 分子式 | C26H38N6O2 |
| 分子量 | 466.62 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1332708-14-1.mol |
| 结构式 |  |
CS-2357 性质
| 密度 | 1.164±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | DMF：30mg/mL； DMF:PBS (pH 7.2) (1:5)：0.1 mg/mL； DMSO：20mg/mL；乙醇：10mg/mL |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 13.71±0.46(Predicted) |
PF-4840154 是有效，选择性的大鼠和人 TrpA1 通道激动剂，EC50 分别为 97 和 23 nM。PF-4840154 诱导 TrpA1 介导的小鼠伤害行为。
IC50: 97 nM (rTrpA1), 23 nM (hTrpA1)
PF-4840154 (30 nmol; intraplantar) elicits TrpA1-mediated nocifensive behaviour in mouse.
| Animal Model: | Female CD1 mice (25-30g) (In TrpA1+/+ mice) |
| Dosage: | 30 nmol |
| Administration: | Intraplantar (i.pl) injection |
| Result: | Elicited robust licking behavior. |