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| | NBQX DISODIUM SALT Basic information |
| Product Name: | NBQX DISODIUM SALT | | Synonyms: | NBQX;2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline;FG 9202, 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide hydrate;FG 9202 hydrate disodium salt, 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide hydrate disodium salt;NBQX hydrate disodium salt;2,3-Doxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline;FG 9202 disodium salt hydrate;2,3-Dihydroxy-6-nitrobenzo[f]quinoxaline-7-sulfonamide | | CAS: | 118876-58-7 | | MF: | C12H8N4O6S | | MW: | 336.28 | | EINECS: | | | Product Categories: | Glutamate;Glutamate receptor;Heterocyclic Compounds;Neurochemicals | | Mol File: | 118876-58-7.mol |  |
| | NBQX DISODIUM SALT Chemical Properties |
| Melting point | 361°C | | density | 1.6027 (rough estimate) | | refractive index | 1.6000 (estimate) | | storage temp. | Inert atmosphere,2-8°C | | solubility | methanol: 0.25 mg/mL | | form | solid | | pka | 7.55±0.20(Predicted) | | color | yellow | | Stability: | Freezer at -20°C | | InChIKey | UQNAFPHGVPVTAL-UHFFFAOYSA-N |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | NBQX DISODIUM SALT Usage And Synthesis |
| Chemical Properties | Yellow Crystalline Solid | | Uses | A potent and discriminating antagonist for AMPA binding sites. This compound has neuroprotective properties. | | Uses | NBQX disodium salt hydrate has been used:
- in N-methyl-D-aspartate receptor (NMDAR) kinetic studies
- as an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist for the electrophysiological studies cultured neurons
- in the extracellular solution for current/voltage (I/V) relationship and rectification index experiments in excitatory postsynaptic currents (EPSCs) mediated by NMDA receptors (EPSCNMDAR)
| | Definition | ChEBI: 2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline is a member of naphthalenes and a sulfonic acid derivative. | | General Description | NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline] is a competitive antagonist, which shows high affinity to 2-amino-3-hydroxy-5-methyl-4-isoxazol propionic acid (AMPA) receptor than kainite receptor. | | Biological Activity | Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo . More water soluble disodium salt of NBQX (2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide ). Also available as part of the AMPA Receptor Tocriset™ . | | Biochem/physiol Actions | NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline], an anticonvulsant provides protection against white matter damage in spinal cord crush injury and also protects oligodendrocyte in experimental autoimmune encephalomyelitis (EAE). However, its role in preventing inflammation in EAE is not yet clear. | | storage | Room temperature |
| | NBQX DISODIUM SALT Preparation Products And Raw materials |
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