CSN-B
中文名称 | CSN-B |
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中文同义词 | NUR77激动剂(CYTOSPORONE B);化合物CYTOSPORONE B;(3,5-二羟基-2-辛酰基-苯基)-乙酸乙酯;胞孢子酮B;CYTOSPORONEB游离态;2-(3,5-二羟基-2-辛酰基苯基)乙酸乙酯 |
英文名称 | Csn-B |
英文同义词 | 3,5-Dihydroxy-2-(1-oxooctyl)benzeneacetic acid ethyl ester;3,5-Dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester;Csn-B;ethyl 2-(3,5-dihydroxy-2-octanoylphenyl)acetate;Benzeneacetic acid, 3,5-dihydroxy-2-(1-oxooctyl)-, ethyl ester;N-{2-[(3-CYANO-5,7-DIMETHYL-2-QUINOLINYL)AMINO]ETHYL}-3-METHOXYBE |
CAS号 | 321661-62-5 |
分子式 | C18H26O5 |
分子量 | 322.4 |
EINECS号 | |
相关类别 | 细胞生物学试剂;对照品;抑制剂 |
Mol文件 | 321661-62-5.mol |
结构式 |
CSN-B 性质
沸点 | 471.6±24.0 °C(Predicted) |
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密度 | 1.126±0.06 g/cm3(Predicted) |
储存条件 | -20°C |
溶解度 | 二甲基亚砜:>20mg/mL |
酸度系数(pKa) | 7.54±0.40(Predicted) |
形态 | 结晶固体 |
颜色 | 白色至类白色 |
Target | Value |
Nur77
(Cell-free assay) | 0.278 nM(EC50) |
Cytosporone B targets the ligand binding domain of Nur77, which selectively stimulates the transactivational activity of Nur77. Cytosporone B induces luciferase activity in cells that are cotransfected with GAL4- Nur77 or GAL4-LBD. The EC 50 of cytosporone B for Nur77 is 0.278 nM. Cytosporone B displays robust pro-apoptotic activity in gastric cancer cells BGC-823. 63.5% of the cells are apoptotic when treated with cytosporone B for 48 h. Cytosporone B shows selective effect on cancerous cells. Cytosporone B inhibits proliferation of human gastric cancer BGC-823 cells and human colon cancer SW620 cells by 470%, but it has a modest effect on human lung cancer H1299 cells and human hepatoma HepG2 cells.
In the hepatocytes of wild-type mice, the transcriptional activity of the reporter is induced five-fold with cytosporone B treatment. In wild-type mice, cytosporone B treatment significantly increases glucose levels from 3.2 to 11.4 mM within the first 30 min, and thereafter blood glucose gradually decreased before reaching the initial level after 300 min.
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-N2148 | CSN-B Cytosporone B | 321661-62-5 | 2mg | 770元 |
2024/08/19 | HY-N2148 | CSN-B Cytosporone B | 321661-62-5 | 5mg | 1100元 |