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| | Methyl 4-methoxyacetoacetate Basic information |
| | Methyl 4-methoxyacetoacetate Chemical Properties |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | F | 10 | | HS Code | 29189900 |
| | Methyl 4-methoxyacetoacetate Usage And Synthesis |
| Chemical Properties | colorless to yellow liquid | | Uses | Methyl 4-methoxyacetoacetate has been used in generation of a small focused library of diversely functionalized dihydropyrimidine derivatives via one-pot three-component Biginelli cyclocondensation of β-ketoesters, aldehydes and (thio)ureas. | | Uses | Methyl 4-Methoxyacetoacetate is a reactant in the formation of an abiotic poorphyrinogen in aqueous solution. | | Preparation | The preparation method of a 4-methoxyl group methyl acetoacetate: add solvents tetrahydrofurane in a kettle. and pass into rare gas element, the temperature in the kettle arranging reactor is 15-25℃, industrial sodium hydride and metal alkaline compound is added under whipped state, add solvents tetrahydrofurane again, the mixed solution reaction 4-6h of methyl alcohol and 4-chloro methyl acetoacetate is dripped in less than 20℃, then be warming up to 20-25℃ and continue reaction 4-15h, TLC detection reaction is complete, reduce system temperature to 6-10℃, add the hydrochloric acid soln regulation system pH=5-7 that volumetric molar concentration is 2mol/L, stratification, after separatory, upper strata is concentrated is spin-dried for removing solvents tetrahydrofurane, then colorless product 4-methoxyl group methyl acetoacetate is obtained by wiped film molecular distillation. |
| | Methyl 4-methoxyacetoacetate Preparation Products And Raw materials |
| Raw materials | Butanoic acid, 2,4-dimethoxy-3-oxo-, methyl ester-->Butanoic acid, 3-hydroxy-4-methoxy-, methyl ester-->Butanoic acid, 4-methoxy-3-oxo-
-->Ethanone, 1-(1H-imidazol-1-yl)-2-methoxy--->methyl 4-bromo-3-oxo-butanoate-->Methyl 4-chloro-3-oxo-butanoate | | Preparation Products | 4(1H)-Pyrimidinone, 6-(methoxymethyl)- (9CI)-->5-Thiazolecarboxylicacid,2-amino-4-(methoxymethyl)-,methylester(9CI)-->2-Dimethylaminomethylene-4-methoxy-3-oxo-butyric acid methyl ester |
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