| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing1@energy-chemical.com |
| Products Intro: |
Product Name:Z36 >=98% (HPLC)
CAS:1243148-19-7
Purity:NULL Package:25mg;5mg Remarks:NULL
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:Z36
CAS:1243148-19-7
Package:50mg/RMB 13800;100mg/RMB 17500;25mg/RMB 10600
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Email: |
ordercn@merckgroup.com |
| Products Intro: |
Product Name:Z36
CAS:1243148-19-7
|
1-[3-(dimethylamino)propyl]-5-fluoro-1,3-dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2H-Indol-2-one manufacturers
- Z36
-
- $1980.00 / 50mg
-
2025-07-26
- CAS:1243148-19-7
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | 1-[3-(dimethylamino)propyl]-5-fluoro-1,3-dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2H-Indol-2-one Basic information |
| | 1-[3-(dimethylamino)propyl]-5-fluoro-1,3-dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2H-Indol-2-one Chemical Properties |
| Boiling point | 565.8±50.0 °C(Predicted) | | density | 1.273±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: ≥15mg/mL | | pka | 16.02±0.30(Predicted) | | form | powder | | color | light yellow to dark yellow |
| | 1-[3-(dimethylamino)propyl]-5-fluoro-1,3-dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2H-Indol-2-one Usage And Synthesis |
| Uses | Z36 may be used to study cell signaling th at results in autophagy. | | Biological Activity | Z36 inhibits cell proliferation and induces death in HeLa cells. The cell death induced is via autophagy and autophagic flux.', 'Z36 is a Bcl-XL inhibitor th at induces autophagic cell death independent of apoptosis which distinguishes it from other Bcl-XL and Bcl-2 inhibitors th at induce cancer cell death mainly through apoptosis. Z36 binds to the BH3 binding groove of BCL-XL where it is thought to induce autophagy through blocking the interaction between Bcl-XL/Bcl2 and Beclin 1. |
| | 1-[3-(dimethylamino)propyl]-5-fluoro-1,3-dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2H-Indol-2-one Preparation Products And Raw materials |
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